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Bioavailability And Cv Component Comparison In A Crossover, Zhiming Wang, Vince A. Uthoff
Bioavailability And Cv Component Comparison In A Crossover, Zhiming Wang, Vince A. Uthoff
Conference on Applied Statistics in Agriculture
Two medication formulations are compared using noncompartmental pharmacokinetic (PK) variables. However, more than the ratio of mean effects is of interest. A difference in formulation coeficients of varication (CV), within- or between-subject, is sought. The experimental design chosen is a 2 sequence crossover design of the form ABBA and BAAB, where A and B are two medication formulations. A mixed linear model is defined that contains random effects for subjects and for subject by formulation interactions. The model has fixed effects for the average formulation effects and period effects. The 2 formulations are assumed to have different error terms. The …