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Conference on Applied Statistics in Agriculture
Microarray; tiling array; differential expression; ANOVA model
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Statistical Methods For Affymetrix Tiling Array Data, Gayla Olbricht, Nagesh Sardesai, Stanton B. Gelvin, Bruce A. Craig, R. W. Doerge
Statistical Methods For Affymetrix Tiling Array Data, Gayla Olbricht, Nagesh Sardesai, Stanton B. Gelvin, Bruce A. Craig, R. W. Doerge
Conference on Applied Statistics in Agriculture
Tiling arrays are a microarray technology currently being used for a variety of genomic and epigenomic applications, such as the mapping of transcription, DNA methylation, and histone modifications. Tiling arrays provide high-density coverage of a genome, or a genomic region, through the systematic and sequential placement of probes without regard to genome annotation. In this paper we compare the Affymetrix tiling array to the Affymetrix GeneChip® 3’ expression array and propose methods that address statistical and bioinformatic issues that accompany gene expression data that are generated from Affymetrix tiling arrays. Real data from the model organism Arabidopsis thaliana motivate this …