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Exclusion Criteria And Generalizability In Bipolar Disorder Treatment Trials, Jessie J. Wong, Nev Jones, Christine Timko, Keith Humphreys
Exclusion Criteria And Generalizability In Bipolar Disorder Treatment Trials, Jessie J. Wong, Nev Jones, Christine Timko, Keith Humphreys
Mental Health Law & Policy Faculty Publications
Objective: The current paper reviews the English-language research on exclusion criteria in bipolar disorder treatment trials and discusses how study samples compare to the general bipolar patient population.
Methods: & Results: Across 8 identified studies of exclusion criteria and their impact, between 55% and 96% of people with bipolar disorder would be excluded from treatment research. The number of exclusion criteria varies across bipolar disorder treatment research, with one study estimate of a median of 7 criteria used across studies. The criteria that excluded the greatest number of potential participants were comorbid substance use disorder, suicidal risk, and comorbid medical …