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Impact Of Secondary Reactive Species On The Apparent Decoupling Of Poly(Ethylene Glycol) Diacrylate Hydrogel Average Mesh Size And Modulus, Dany J. Munoz Pinto, S. Samavedi, B. Grigoryan, M. S. Hahn
Impact Of Secondary Reactive Species On The Apparent Decoupling Of Poly(Ethylene Glycol) Diacrylate Hydrogel Average Mesh Size And Modulus, Dany J. Munoz Pinto, S. Samavedi, B. Grigoryan, M. S. Hahn
Dany J. Munoz Pinto
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels are widely used in biotechnology due to their in situ crosslinking capacity and tunable physical properties. However, as with all single component hydrogels, the modulus of PEGDA networks cannot be tailored independently of mesh size. This interdependence places significant limitations on their use for defined, 3D cell-microenvironment studies and for certain controlled release applications. The incorporation of secondary reactive species (SRS) into PEGDA hydrogels has previously been shown to allow the identification of up to 6 PEGDA hydrogel formulations for which distinct moduli can be obtained at consistent average mesh size (or vice versa). However, …
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Dany J. Munoz Pinto
Collagen hydrogels have been widely investigated as scaffolds for vascular tissue engineering due in part to the capacity of collagen to promote robust cell adhesion and elongation. However, collagen hydrogels display relatively low stiffness and strength, are thrombogenic, and are highly susceptible to cell-mediated contraction. In the current work, we develop and characterize a sequentially-formed interpenetrating network (IPN) that retains the benefits of collagen, but which displays enhanced mechanical stiffness and strength, improved thromboresistance, high physical stability and resistance to contraction. In this strategy, we first form a collagen hydrogel, infuse this hydrogel with poly(ethylene glycol) diacrylate (PEGDA), and subsequently …