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Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine
Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine
Williams Honors College, Honors Research Projects
The main objective of this honor’s project is to encapsulate drugs with different molecular weights inside of chitosan-heparin based nanoparticles (Cs-Hep NPs). Three different drugs with low (NNC), medium (IFN-γ), and large (BSA) molecular weights were chosen in order to compare all types of drugs and how they react with the nanoparticles. Analysis of particle size, zeta potential, and a release study was performed. The release took place over a 168-hour time period and liquid samples were taken throughout. The hypothesis was that the molecular weight of the drug will correlate to the physical properties of the nanoparticles. The results …
Polyhexamethylene Biguanide Release By Chitosan-Heparin Nanoparticles, Jacob Ress
Polyhexamethylene Biguanide Release By Chitosan-Heparin Nanoparticles, Jacob Ress
Williams Honors College, Honors Research Projects
Chitosan and heparin were used to synthesize nanoparticles using polyelectrolyte complexation. The optimal mixing ratio was determined to be 1:4 by studying the particle characteristics of zeta potential and dynamic light scattering of the ratios 1:2, 1:3, 1:4, 1:5 and 1:6 (chitosan: heparin). The particles were loaded with the antibiotic polyhexamethylene biguanide (PHMB) and the release was measured over 335 hours using the dialysis membrane incubation method and detected via ultraviolet-visible (UV-Vis) spectroscopy. Around 80% of the encapsulated PHMB was released over the measured period. The goal of this part of the study was to determine the drug release behavior …