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Full-Text Articles in Engineering
Modeling The Effect Of P53 On Tumor Heterogeneity And The Mutator Phenotype, Melissa Ryan, Matthew J. Berryman, Derek Abbott
Modeling The Effect Of P53 On Tumor Heterogeneity And The Mutator Phenotype, Melissa Ryan, Matthew J. Berryman, Derek Abbott
Faculty of Engineering - Papers (Archive)
p53 is an important gene, involved in apoptosis (programmed cell death), DNA repair, and cell cycle progression. We explore the selective advantages and disadvantages of mutations in the p53 gene on tumor cells, and the heterogeneity of tumor cell populations. Based on an evolutionary computational approach, our model considers changes in mutation rate caused by lack of DNA repair processes, and the lack of apoptosis caused by mutations in p53. We find that the degree of robustness of p53 to mutations has a significant effect on the tumor heterogeneity and “fitness”, with clinical consequences for people who inherit p53 mutations.
Hierarchical Bayesian Modeling Of The Movement Of Ice Streams, L M. Berliner, Noel A. Cressie, Kenneth Jezek, Yongku Kim, Calvin Lam
Hierarchical Bayesian Modeling Of The Movement Of Ice Streams, L M. Berliner, Noel A. Cressie, Kenneth Jezek, Yongku Kim, Calvin Lam
Faculty of Engineering and Information Sciences - Papers: Part A
Modern studies of the behaviors of glaciers, ice-sheets, and ice-streams rely heavily on both observations and physically based models. Data acquired via remote-sensing provide critical information on geometry and movement of ice over large sections of the Antarctic and Greenland. Though these datasets represent significant advances in terms of spatial coverage and the range of processes we can observe, the physical systems to be modeled are nevertheless incompletely observed. Uncertainties associated with measurement errors are also present. In addition, physical models are also subject to uncertainties. Hence, there is a need for combining observations and models in a fashion that …
Dynamic Modeling And Simulation Of A Multi Effect Humidification-Dehumidification Desalination Unit, Mohammed I. Sohel, B Dawoud
Dynamic Modeling And Simulation Of A Multi Effect Humidification-Dehumidification Desalination Unit, Mohammed I. Sohel, B Dawoud
Faculty of Engineering and Information Sciences - Papers: Part A
Recently solar distillation using Multi Effect Humidification-dehumidification (MEH) cycle is receiving special attention. In this communication detailed models of MEH are presented that take into account most of the dynamic behavior with reasonable accuracy. Using these models simulation was carried out and the results of simulation were discussed in this paper. To find out the competence of the newly developed models, some of the simulation results were compared with the available experimental data in the literature. It turned out that the result of simulation give a very good agreement with the experimental data. The maximum deviation between simulation and experimental …