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Full-Text Articles in Engineering

Fabrication And Flow Dynamics Analysis Of Micromixer For Lab-On-A-Chip Devices, Md Fazlay Rubby Dec 2020

Fabrication And Flow Dynamics Analysis Of Micromixer For Lab-On-A-Chip Devices, Md Fazlay Rubby

Theses and Dissertations

The miniaturized systems designed for lab-on-a-chip (LOC) technologies are generally implemented with a micro-scale mixer to provide intimate contact between the reagent molecules for interactions and chemical reactions. The exponential increase of research in microfabrication and microfluidic applications highlights the importance of understanding the theory and mechanism that governs mixing at the microscale level. In this study, the fabrication of an active and passive micromixer was discussed. The optimized state of art soft lithography and 3D printing was used as a microfabrication technique. The challenges at different fabrication steps were presented along with the modifications. Microelectrodes were integrated with the …


3d Printing For Solving Part Obscolescence, Ayman G. Alqarni Sep 2020

3d Printing For Solving Part Obscolescence, Ayman G. Alqarni

Theses and Dissertations

The purpose of this research was to highlight the issue of parts obsolescence and to highlight the possibility of using alternative methods to overcome parts shortage. Specifically, this thesis sought to answer the research question: is the three-dimensional printing technology (3D) an applicable approach to overcome part obsolescence. The research question was answered through data research and survey analysis. Notwithstanding, the diminished manufacturing sources and material shortages (DMSMS) management and other existing approaches, such as forecasting, contracting, and reverse engineering (RE), were discussed briefly in the literature review and profoundly in chapter IV to differentiate among applicable existing solutions toward …


Conduction Mapping For Quality Control Of Laser Powder Bed Fusion Additive Manufacturing, Chance M. Baxter Mar 2020

Conduction Mapping For Quality Control Of Laser Powder Bed Fusion Additive Manufacturing, Chance M. Baxter

Theses and Dissertations

A process was developed to identify potential defects in previous layers of Selective Laser Melting (SLM) Powder Bed Fusion (PBF) 3D printed metal parts using a mid-IR thermal camera to track infrared 3.8-4 m band emission over time as the part cooled to ambient temperature. Efforts focused on identifying anomalies in thermal conduction. To simplify the approach and reduce the need for significant computation, no attempts were made to calibrate measured intensity, extract surface temperature, apply machine learning, or compare measured cool-down behavior to computer model predictions. Raw intensity cool-down curves were fit to a simplified functional form designed to …


Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey Jan 2020

Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey

Theses and Dissertations

Diseases and disorders in the human body are considered abnormalities of proper cellular function. Understanding the signal transduction mechanisms that cause these abnormalities is crucial to developing earlier detection methods, better treatment options and effective cures. While current diagnostic procedures are powerful tools in diagnosing diseases, they are ineffective in informing physicians on the real-time behavior of the signal transduction mechanisms associated with diseases and disorders. Currently, disease progression is monitored over time through routine patient visits and testing by one or more of the above techniques. By developing an approach that can monitor structural and conformational changes of proteins …