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Full-Text Articles in Engineering
Modification Of Lipid Microenvironments On Solid Support Structures For Use In Transmembrane Protein Assays, William J. Houlihan
Modification Of Lipid Microenvironments On Solid Support Structures For Use In Transmembrane Protein Assays, William J. Houlihan
Dissertations and Theses
Gamma-Secretase (γ-secretase) is a transmembrane protease of increasing interest, which has been shown to have significant connections to both cancer and Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane protein whose cleavage may result in the formation of β-amyloid plaques in the brain. Notch-1 and APP are widely studied proteins that have substantial impacts on the development and proliferation of cancer and Alzheimer’s disease, respectively. Notch-1 partakes in the signaling of apoptosis in damaged and mutated cells, thus its cleavage by γ-secretase within the plasma membrane has ramifications on cell growth …
Intensification Of Gas Absorption In A Downward Flow Microbubble Bioreactor, Manizheh Ansari
Intensification Of Gas Absorption In A Downward Flow Microbubble Bioreactor, Manizheh Ansari
Dissertations and Theses
Bioreactors are of interest for value-upgrading of stranded or waste industrial gases, such as CO, CH4, or syngas. Process economics requires reduction of reactor cost and size while maintaining high production rate via rapid delivery of gas feedstock to the liquid phase which in turn requires a high volumetric mass transfer rate (). One strategy to achieve this goal is to increase interfacial area density, a, to >3000 m2 m-3, while minimizing use of energy. Here we show a novel reactor column design that uses a micro-jet array to break feedstock at ambient pressure …