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Optical Spectrsocopy Of Murine Breast Tumor To Distinguish Indolent From Aggressive Disease, Joel Rodriguez Troncoso
Optical Spectrsocopy Of Murine Breast Tumor To Distinguish Indolent From Aggressive Disease, Joel Rodriguez Troncoso
Biomedical Engineering Undergraduate Honors Theses
Breast cancer accounts for 30% of all cancer. Metastasis is the primary cause of death among breast cancer patients. Additionally, current molecular profiling methods such as Oncotype DX, which are expensive and not widely available at all clinical facilities, only determine the risk of recurrence after treatment. Therefore, there are no current method capable of identifying metastatic patients in advance.As a result, there is an unmet clinical need to develop a cost-effective prognostic to differentiate between indolent and aggressive breast tumors. In this study, we implemented diffuse reflectance spectroscopy (DRS) system to evaluate functional changes in tumor xenografts originated from …
Modeling And Validation Of Tissue Optical Properties In The Photon Transport Regime, Katelyn Heath
Modeling And Validation Of Tissue Optical Properties In The Photon Transport Regime, Katelyn Heath
Biomedical Engineering Undergraduate Honors Theses
Early detection of changes in epithelial cells, such as the development of neoplastic formations seen in epithelial dysplasia, can indicate regions of the epithelial tissue that are at a high risk for cancerous formation. Using concepts from diffuse reflectance spectroscopy, a Monte Carlo model was developed to predict the reflectance measured by a detector at a small source-detector separation on a microendoscope. The Monte Carlo results were then used to calculate a mathematical relationship between the reflectance and distance that can be used to determine optical properties in a tissue sample. This model was validated with liquid phantoms of specified …
Vector Flow Imaging In Pediatric Cardiology - Extracting And Validating Data, Mason Belue
Vector Flow Imaging In Pediatric Cardiology - Extracting And Validating Data, Mason Belue
Biomedical Engineering Undergraduate Honors Theses
In the field of bedside cardiac diagnostic imaging, Doppler Ultrasound (DU) is the gold standard for diagnosing heart conditions. The largest benefit of DU is its ability to noninvasively image cardiac flow and allow the estimation of blood velocity and quantification of anatomical disease. However, to get correct velocity estimation, the position of the transducer in relation to the flow field needs to be known. This is the problem of angle/direction dependency and limits DUs accuracy when imaging in areas where perfect alignment or exact position of the transducer in relation to flow field is not possible or known, such …
Investigation Of Acute Radiation-Induced Changes In Oxygenation In A Murine Breast Tumor Model, Alaa Abdelgawad
Investigation Of Acute Radiation-Induced Changes In Oxygenation In A Murine Breast Tumor Model, Alaa Abdelgawad
Biomedical Engineering Undergraduate Honors Theses
Around 50-60% of all cancer patients undergo radiation therapy. Although some patients show complete response with no recurrence, a significant proportion of the population still develop radiation resistance. It is important to identify tumor resistance at early stages of therapy in order to adjust treatment protocol and avoid extra exposure to radiation. Current methods to assess treatment response are only limited to anatomical measurements of tumor volume after therapy. Novel approaches that shed the light on any functional information during the course of radiotherapy could significantly improve our ability to identify patients who do not respond to radiation therapy. Diffuse …