Engineering Commons^™

Bio-Mechanical Characterization Of Adherent Cell Layers With A Pdms Cantilever, Merrel Truly Holley

LSU Doctoral Dissertations

In the last few decades, the mechanical characteristics of human cells has been linked to many physiological processes and pathological conditions, illustrating the importance as effective biomarkers. Mounting research has shown the mechanical force between cells and the extracellular matrix (ECM) plays a vital role in cellular processes such as tissue homeostasis, wound healing, cancer metastasis, and the progression of various diseases. This mechanical force, or the force that a cell produces on its surroundings, is termed as the cellular traction force (CTF). Precise characterization of the CTF can expand our knowledge of these important cellular processes as well as …

Unidirectional And Nonreciprocal Nanophotonic Devices Based On Graphene And Magneto-Optical Materials, Vahid Foroughi Nezhad

LSU Doctoral Dissertations

In this dissertation, we first introduce compact tunable spatial mode converters for graphene parallel plate (GPP) waveguides. The converters are reciprocal and based on spatial modulation of graphene’s conductivity. The wavelength of operation of the mode converters is tunable in the mid-infrared wavelength range by adjusting the chemical potential of a strip on one of the graphene layers of the GPP waveguides. We also introduce optical diodes for GPP waveguides based on a spatial mode converter and a coupler, which consists of a single layer of graphene placed in the middle between the two plates of two GPP waveguides. \par …

Neurostimulator With Waveforms Inspired By Nature For Wearable Electro-Acupuncture, Jose Aquiles Parodi Amaya

LSU Doctoral Dissertations

The work presented here has 3 goals: establish the need for novel neurostimulation waveform solutions through a literature review, develop a neurostimulation pulse generator, and verify the operation of the device for neurostimulation applications.

The literature review discusses the importance of stimulation waveforms on the outcomes of neurostimulation, and proposes new directions for neurostimulation research that would help in improving the reproducibility and comparability between studies.

The pulse generator circuit is then described that generates signals inspired by the shape of excitatory or inhibitory post-synaptic potentials (EPSP, IPSP). The circuit analytical equations are presented, and the effects of the circuit …

Graph Information Processing For Artificial Intelligence, Limeng Pu

LSU Doctoral Dissertations

In the last decade, techniques for artificial intelligence (AI) has advanced tremendously, which lead to solutions to many problems that have long-troubled us. Such examples include image/video recognition, speech recognition, and 3D scenario recognition. As the tool become more and more powerful, we started to explore data types that have never been handled in an AI fashion. Graph is undoubtedly the first one that comes to mind. Many important real-life data is or can be represented as graphs or networks: social networks, communication networks, protein-protein interaction networks, molecular structures, etc. Yet very little attention has been devoted to the study …

System Identification Based On Errors-In-Variables System Models, Hyundeok Kang

LSU Doctoral Dissertations

We study the identification problem for errors-in-variables (EIV) systems. Such an EIV model assumes that the measurement data at both input and output of the system involve corrupting noises. The least square (LS) algorithm has been widely used in this area. However, it results in biased estimates for the EIV-based system identification. In contrast, the total least squares (TLS) algorithm is unbiased, which is now well-known, and has been effective for estimating the system parameters in the EIV system identification.

In this dissertation, we first show that the TLS algorithm computes the approximate maximum likelihood estimate (MLE) of the system …

Cost Effective, Highly Efficient Wireless Power Transfer Systems For Ev Battery Charging, Amir Masoud Bozorgi

LSU Doctoral Dissertations

The impact of changing inner diameter of wireless power transfer (WPT) coils on coupling coefficient is studied. It is demonstrated that at a certain outer and inner coil diameter, turn space variation has minor effect on the coupling coefficient. Next, two compensation networks, namely primary LCC and secondary LCC, which offer load-independent voltage transfer ratio and zero voltage switching for WPT, are presented. For both compensation networks, the condition for having zero voltage switching operation are derived. In addition, load-independent voltage transfer ratio (VTR) frequencies are obtained and VTR at each frequency is derived. Then, required equations for calculation of …

Developing An Optomechanical Approach For Characterizing Mechanical Properties Of Single Adherent Cells, Ali Mehrnezhad

LSU Doctoral Dissertations

Mechanical properties of a cell reflect its biological and pathological conditions including cellular disorders and fundamental cellular processes such as cell division and differentiation. There have been active research efforts to develop high-throughput platforms to mechanically characterize single cells. Yet, many of these research efforts are focused on suspended cells and use a flow-through configuration. Therefore, adherent cells are detached prior to the characterization, which seriously perturbs the cellular conditions. Also, methods for adherent cells are limited in their throughput.

My study is aimed to fill the technical gap in the field of single cell analysis, which is a high-throughput …

Optimal And Efficient Decision-Making For Power System Expansion Planning, Mahdi Mehrtash

LSU Doctoral Dissertations

A typical power system consists of three major sectors: generation, transmission, and distribution. Due to ever increasing electricity consumption and aging of the existing components, generation, transmission, and distribution systems and equipment must be analyzed frequently and if needed be replaced and/or expanded timely. By definition, the process of power system expansion planning aims to decide on new as well as upgrading existing system components in order to adequately satisfy the load for a foreseen future.

In this dissertation, multiple economically optimal and computationally efficient methods are proposed for expanding power generation, transmission, and distribution systems. First, a computationally efficient …

A Model-Based Framework For The Smart Manufacturing Of Polymers, Santiago D. Salas Ortiz

LSU Doctoral Dissertations

It is hard to point a daily activity in which polymeric materials or plastics are not involved. The synthesis of polymers occurs by reacting small molecules together to form, under certain conditions, long molecules. In polymer synthesis, it is mandatory to assure uniformity between batches, high-quality of end-products, efficiency, minimum environmental impact, and safety. It remains as a major challenge the establishment of operational conditions capable of achieving all objectives together. In this dissertation, different model-centric strategies are combined, assessed, and tested for two polymerization systems.

The first system is the synthesis of polyacrylamide in aqueous solution using potassium persulfate …