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Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury, James K. Nolan, Tran N. H. Nguyen, Mara Fattah, Jessica C. Page, Riyi Shi, Hyowon Lee
Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury, James K. Nolan, Tran N. H. Nguyen, Mara Fattah, Jessica C. Page, Riyi Shi, Hyowon Lee
Weldon School of Biomedical Engineering Faculty Publications
Excessive glutamate release following traumatic spinal cord injury (SCI) has been associated with exacerbating the extent of SCI. However, the mechanism behind sustained high levels of extracellular glutamate is unclear. Spinal cord segments mounted in a sucrose double gap recording chamber are an established model for traumatic spinal cord injury. We have developed a method to record, with micro-scale printed glutamate biosensors, glutamate release from ex vivo rat spinal cord segments following injury. This protocol would work equally well for similar glutamate biosensors.
Application Of Micro-Scale 3d Printing In Pharmaceutics, Andrew Kjar, Yu Huang
Application Of Micro-Scale 3d Printing In Pharmaceutics, Andrew Kjar, Yu Huang
Biological Engineering Faculty Publications
3D printing, as one of the most rapidly-evolving fabrication technologies, has released a cascade of innovation in the last two decades. In the pharmaceutical field, the integration of 3D printing technology has offered unique advantages, especially at the micro-scale. When printed at a micro-scale, materials and devices can provide nuanced solutions to controlled release, minimally invasive delivery, high-precision targeting, biomimetic models for drug discovery and development, and future opportunities for personalized medicine. This review aims to cover the recent advances in this area. First, the 3D printing techniques are introduced with respect to the technical parameters and features that are …