Engineering Commons^™

Genotype Combinations Linked To Phenotype Subgroups In Autism Spectrum Disorders, Junya Zhao, Thy Nguyen, Jonathan Kopel, Perry B. Koob, Donald A. Adieroh, Tayo Obafemi-Ajayi

Electrical and Computer Engineering Faculty Research & Creative Works

This paper investigates a computational model that allows for systematic comparison of phenotype data with genotype (Single Nucleotide Polymorphisms (SNPs)) data based on machine learning techniques to identify discriminant genotype markers associated with the phenotypic subgroups. The proposed discriminant SNP identifier model is empirically evaluated using Autism Spectrum Disorder (ASD) simplex sample. Six phenotype markers were selected to cluster the sample in a hexagonal lattice format yielding five multidimensional subgroups based on extremities of the phenotype markers. The SNP selection model includes random subspace selection of SNPs in conjunction with feature selection algorithms to determine which set of SNPs were …