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Full-Text Articles in Engineering
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Wayne State University Dissertations
With a broad spectrum of therapies available for treating breast cancer, the need for personalized medicine tailoring the cure according to phenotype is evident. Such an approach may be fully realized with the development of quantitative imaging technologies for disease detection, staging and diagnosis, without increasing patient burden. Immuno-positron emission tomography (PET) combines the targeted specificity of antibodies with the sensitivity of PET for whole body imaging by targeting molecular features amplified in lesions. ImmunoPET probes targeting different antigens and their utility to measure response to treatment were explored. 89Zr-trastuzumab was employed as a surrogate readout of Src inhibition after …
Optimization Of Underbody Blast Energy-Attenuating Seat Mechanisms Using Modified Madymo Hybrid Iii And Human Body Models, Kelly Erin Bryan Bosch
Optimization Of Underbody Blast Energy-Attenuating Seat Mechanisms Using Modified Madymo Hybrid Iii And Human Body Models, Kelly Erin Bryan Bosch
Wayne State University Dissertations
Energy attenuating (EA) blast seats, although not new to the market, have not been fully characterized with respect to energy attenuation capability and the resulting effects on occupant protection. EA seats utilize stroking mechanisms to absorb energy and reduce the vertical forces imparted on the occupant’s pelvis and lower spine complex. Although a variety of EA seats are available on the market, the fundamental question behind how to optimize the force and deflection rates of the EA mechanisms to effectively reduce occupant injury has not yet been answered. Using modeling and simulation techniques, this research developed a tool to determine …
Gentamicin-Modified Nanocarriers For Placental Targeted Drug Delivery To Treat Pregnancy-Related Complications, Ali Alfaifi
Gentamicin-Modified Nanocarriers For Placental Targeted Drug Delivery To Treat Pregnancy-Related Complications, Ali Alfaifi
Wayne State University Dissertations
Diseases of pregnancy are the leading cause of maternal and neonatal morbidity and mortality affecting more than 20% (26 million) of all pregnancies annually. Those diseases include preeclampsia, preterm labor, intrauterine growth restriction and gestational diabetes, many of which are caused by compromised functions of the placenta. Placenta is a specialized organ that is only present during pregnancy where it creates a maternal-fetal interface that is responsible for many functions that contribute to the development of the fetus. Unfortunately, there is currently no treatment for any of those diseases. Our work focuses on the development of a novel nanoplatform that …
Celiac Disease: A Physiological Overview And Possible Future Work With Emphasis On Raman Spectroscopy, Katlyn Curtin Mehne
Celiac Disease: A Physiological Overview And Possible Future Work With Emphasis On Raman Spectroscopy, Katlyn Curtin Mehne
Wayne State University Theses
Celiac Disease is a condition whereby ingesting Gluten causes an autoimmune reaction in the intestines with adverse effects throughout the body. Although statistic analysis estimates that 1% of the general population is affected by this condition, the diagnosis and treatment research lacks in key areas of understanding. This is a summary of current research and physiological information on the impact of Celiac Disease. In the last twenty years, Raman Spectroscopy assisted in diagnosis and treatment of various other ailments. In this case, Raman Spectroscopy can be used to research immunological cells involved in Celiac Disease and further research.