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Full-Text Articles in Engineering
Engineering Nanomaterials For Imaging And Therapy Of Bacteria And Biofilm-Associated Infections, Akash Gupta
Engineering Nanomaterials For Imaging And Therapy Of Bacteria And Biofilm-Associated Infections, Akash Gupta
Doctoral Dissertations
Infections caused by multidrug-resistant (MDR) bacteria pose a serious global burden of mortality, causing thousands of deaths each year. The “superbug” risk is further exacerbated by chronic infections generated from antibiotic-resistant biofilms that are highly resistant to available treatments. Synthetic macromolecules such as polymers and nanoparticles have emerged as promising antimicrobials. Moreover, ability to modulate nanomaterial interaction with bacterial cellular systems plays a pivotal role in improving the efficacy of the strategy. In the initial studies on engineering nanoparticle surface chemistry, I investigated the role played by surface ligands in determining the antimicrobial activity of the nanoparticles. In further study, …
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin
Iron-Containing Nanoparticles For The Treatment Of Chrionic Biofilm Infections In Cystic Fibrosis, Leisha M. A. Martin
Nanoscience and Microsystems ETDs
Cystic fibrosis (CF) is the most common genetic disease resulting in the morbidity and mortality of Caucasian children and adults worldwide. Due to a genetic mutation resulting in malfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, CF patients produce highly viscous mucus in their respiratory tract. This leads to impairment of the mucociliary clearance of inhaled microbes. In addition to reduced microbial clearance, anoxic environmental conditions in the lungs promote biofilm-mode growth of the pathogenic bacterial species Pseudomonas aeruginosa. Chronic infections of P. aeruginosa begin in early childhood and typically persist until respiratory failure and death result. The …
Form Stable Phase-Change Materials, Russell Dent, Marjan Kashfipour, Nitin Mehra, Jiahua Zhu
Form Stable Phase-Change Materials, Russell Dent, Marjan Kashfipour, Nitin Mehra, Jiahua Zhu
Williams Honors College, Honors Research Projects
This work investigates the use of two different polyols, xylitol (Xyl) and erythritol (Ery), in conjunction with boron nitride (BN) aerogels, for the purpose of creating thermally conductive composites. While the BN filler in Xyl composites achieved a high anisotropic thermal conductivity of up to 4.53 W/m-K at 18.2 weight percent filler loading, they do not exhibit good phase-change material qualities due to a low solidification enthalpy even at low cooling rates. Alternatively, the BN-Ery composites have shown promising results with a solidification enthalpy of 225.14 J/g and a melting enthalpy of 385.84 J/g at a heat rate of 5 …