Engineering Commons^™

Material And Regenerative Properties Of An Osteon-Mimetic Cortical Bone-Like Scaffold, Danial Barati, Ozan Karaman, Seyedsina Moeinzadeh, Safaa Kader, Esmaiel Jabbari

Faculty Publications

The objective of this work was to fabricate a rigid, resorbable and osteoconductive scaffold by mimicking the hierarchical structure of the cortical bone. Aligned peptide-functionalize nanofiber microsheets were generated with calcium phosphate (CaP) content similar to that of the natural cortical bone. Next, the CaP-rich fibrous microsheets were wrapped around a microneedle to form a laminated microtube mimicking the structure of an osteon. Then, a set of the osteon-mimetic microtubes were assembled around a solid rod and the assembly was annealed to fuse the microtubes and form a shell. Next, an array of circular microholes were drilled on the outer …