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Full-Text Articles in Engineering
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF, …
The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie
The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie
Boise State University Theses and Dissertations
Implant geometry is a significant factor in determining knee stability and patient satisfaction following total knee replacement (TKR). Ineffective muscle recruitment, impaired joint functionality and increased implant wear are consequences of an unstable knee replacement. Current knee laxity evaluation techniques are limited in their ability to account for the muscular response to knee instability. This study utilizes a subject specific lower-body musculoskeletal finite element (FE) model with dynamic muscle loading to evaluate implant laxity during activities of daily living. The effect of varying implant conformity on the muscle forces required to maintain a target kinematic profile during simulated laxity testing …
On-Demand Label Production, Robert A. Zimmerman
On-Demand Label Production, Robert A. Zimmerman
Master's Theses
The production and approval process for the various labels used in clinical trials wastes significant time and resources through the need to outsource label production or rely on large reams of pre-cut label stock for each revision throughout the process. An in-house, on-demand label printing and cutting system is a potential remedy to this waste. Previous work by Cheadle et al. resulted in a functional electomechanical prototype of the label cutting aspect of this research, capable of rudimentary linear cuts. In this continued research, emphasis was placed on improved label cutting capabilities and creating PC control software for label design. …
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Biomedical Engineering
This document describes a background on current ultrasound technologies and the troubles that have inspired the need for a hands-free ultrasound transducer device, as well as the regulatory requirements, like patents and standard codes, for the intended invention. It also explains the Stage Gate Review process used to project plan the design of the device, a description of the final design and how it was developed, and the IQ/OQ/PQ. The objectives necessary to design this device, in order to meet all the requirements of the sponsor, are also summarized here. The design process including manufacturing instructions, prototype evolution, and the …
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Biomedical Engineering
This Final Project Report provides the reader with a comprehensive detailing of all of the actions and work that has been completed for this Senior Design Project. In this report, the Cal Poly Biomedical Engineering Senior Project Team will discuss some background on the existing Mark I Flash-Mold Machine currently in use by Gesea Biosciences, background information on Gesea Biosciences, the Customer Requirements and Design Specifications of the new machine, Quality Engineering considerations, design concepts discussed, design concepts chosen, safety considerations, prototype development, manufacturing, testing protocols, and testing results, etc.
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Williams Honors College, Honors Research Projects
This paper will detail the design process of developing a Z-shaped foot and ankle internal fixation plating system. Group 6: Plates for the Sole was made up of 5 team members, who worked together to accommodate their client’s request to complete a biomechanical analysis of a Z-Plate design and a construct a prototype. The Z-Plate’s purpose is to provide podiatrists with a new solution that can fit nicely on the small, irregular bones of the foot, while also remaining strong enough to withstand the forces and torques of the foot.
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Williams Honors College, Honors Research Projects
The main objective of this project was to create a prosthetic arm for a 15 year old boy named Jaiden Foden. Jaiden was born with only one fully developed limb as a result of a genetic disorder, Hanhart Syndrome II. His right arm becomes a residual limb below the elbow, but has two fingers which act in a “claw-like” movement. Jaiden’s left arm becomes a residual limb above the elbow, and his left leg becomes a residual limb above the knee. The goal of the arm was to increase Jaiden’s overall independence and to help in completing daily tasks, such …
Easy Adjustable Protective Helmet, Ryan Balash
Easy Adjustable Protective Helmet, Ryan Balash
Williams Honors College, Honors Research Projects
Akron Children’s Hospital and The University of Akron’s Biomedical Engineering Design Team Engineering Forward have paired together to improve medical adapted helmets for post-operative and disabled patients. An issue is the helmets are only produced in a couple of sizes. Also, it is a tedious process to constantly adjust the pressure on the patient’s cranium within a trial-and-error process. Engineering Forward plans to improve the effectiveness of this helmet by creating an adjustable helmet that can read the pressure on a patient’s head. The caregiver can then make the necessary adjustments to the helmet to accommodate the patient. Documents of …
The Wrist Brace Project, Nathan Nicholas
The Wrist Brace Project, Nathan Nicholas
Williams Honors College, Honors Research Projects
This paper outlines the engineering design process of creating a specialized wrist brace for a local child. This project was completed by a team of senior Biomedical Engineering students.