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Novel Calibrated Short Tr Recovery (Castrr) Method For Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast In Blood Flow Measurements In Mice, Scott W. Thalman, David K. Powell, Ai-Ling Lin
Novel Calibrated Short Tr Recovery (Castrr) Method For Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast In Blood Flow Measurements In Mice, Scott W. Thalman, David K. Powell, Ai-Ling Lin
Biomedical Engineering Faculty Publications
The goal of the study was to develop a novel, rapid Calibrated Short TR Recovery (CaSTRR) method to measure the brain-blood partition coefficient (BBPC) in mice. The BBPC is necessary for quantifying cerebral blood flow (CBF) using tracer-based techniques like arterial spin labeling (ASL), but previous techniques required prohibitively long acquisition times so a constant BBPC equal to 0.9 mL/g is typically used regardless of studied species, condition, or disease. An accelerated method of BBPC correction could improve regional specificity in CBF maps particularly in white matter. Male C57Bl/6N mice (n = 8) were scanned at 7T using CaSTRR …
Soft Palate Modification Using A Collagen Crosslinking Reagent For Equine Dorsal Displacement Of The Soft Palate And Other Upper Airway Breathing Disorders, Stephanie Hunt, Jonathan Kuo, Fabio A Aristizabal, Matt Brown, Abhijit R. Patwardhan, Thomas Hedman
Soft Palate Modification Using A Collagen Crosslinking Reagent For Equine Dorsal Displacement Of The Soft Palate And Other Upper Airway Breathing Disorders, Stephanie Hunt, Jonathan Kuo, Fabio A Aristizabal, Matt Brown, Abhijit R. Patwardhan, Thomas Hedman
Biomedical Engineering Faculty Publications
The mechanical properties of the soft palate can be associated with breathing abnormalities. Dorsal displacement of the soft palate (DDSP) is a naturally occurring equine soft palate disorder caused by displacement of the caudal edge of the soft palate. Snoring and a more serious, sometimes life-threatening, condition called obstructive sleep apnea (OSA) are forms of sleep-related breathing disorders in humans which may involve the soft palate. The goal of this study was to investigate the effect of injecting the protein crosslinker genipin into the soft palate to modify its mechanical properties for the treatment of equine DDSP with potential implications …