Engineering Commons^™

Nanocellulose Fibers As A Potential Material For Orthopedic Implantation Application, David Gregg Holomakoff

Electronic Theses and Dissertations

The field of biomaterials is of immense importance and will continue to grow and develop in the coming years. Novel materials, as well as new approaches for use of existing materials, are sought after now more than ever. Current metal orthopedic implants have an over engineered stiffness and Young’s modulus, causing a phenomenon called stress shielding. Metal implants absorb the majority of force typically exerted on bone and the osteocytes within. When osteocytes fail to sense mechanical forces bones become less dense and weaken, causing possible fracture and other complications. A new orthopedic material is needed matching Young’s modulus of …

Nanosilica Based 3d Printed Scaffold Facilitate Osteoblast Mineral Formation, Tugba Cebe

Material Science and Engineering Theses

Bone has the ability to heal fractures so long as the size of the fracture is sufficiently small. If the defect is large or of critical size, a filling material or graft will be needed to help bone union. Among all the available methods to address this medical condition, the common drawback of grafts is that they are limited in supply since a biological site or organism is needed to harvest the biological graft. As a new approach, researchers have been working with bioceramics and biopolymers for their use in bone tissue engineering. In this work, chitosan was modified with …

Multi-Scale Assessment Of Bone Mechanics And The Mineral Phase Of Intramuscular Bone Of Atlantic Herring Fish, Svetlana Zeveleva

Dissertations and Theses

Bone tissue is a complex composite structure made up of a soft organic phase consisting of collagen I and non-collagenous proteins, and a hard inorganic phase consisting of mineral nanoplatelets. Given it’s compositional properties, bone is a unique stiff, tough, and strong biomaterial, making it exceptionally difficult to synthesize ex vivo. While the complete hierarchical structure may change with age and population, the basic building block components of mineralized collagen fibrils, are preserved. This study uses a model of intramuscular bone of the Atlantic herring fish, which present a simple structure, and no process of remodeling.

A multi-scale approach …

Nanoindentation Properties Of Newly Formed Bone Surrounding Dental Implants Treated With E7-Modified Rbmp-2 Peptides, Ryan Doud

All ETDs from UAB

Statement of Purpose: Use of titanium dental implants for treatment of partial or total edentulism has been well documented since the 1980s with consistent long term results. Osseointegration of these implants can be complicated by insufficient bone after healing of extraction sockets or systemic conditions such as osteoporosis or diabetes. Surface modifications, such as grit blasting (mechanical abrasion) or calcium phosphate (CaP) (chemical treatment) can improve healing time and bone quality around an implant. Our study combined a CaP coating with recombinant bone morphogenetic protein-2 (rBMP-2) mimetic peptide and the polyglutamate domain E7. We used nanoindentation to compare the elastic …