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Mathematical Model Of Plasma Membrane Electrophysiology In A Single Pericyte Cell, Asad Mirza, Arash Moshkforoush
Mathematical Model Of Plasma Membrane Electrophysiology In A Single Pericyte Cell, Asad Mirza, Arash Moshkforoush
Undergraduate Research at FIU (URFIU) Conference
A mathematical model of a single pericyte cell was developed based on data available in literature. The model incorporates the dynamic behavior of 1) plasma membrane currents; 2) release and uptake of Ca2+ by the sarcoplasmic reticulum; 3) tracking of cytosolic Ca2+, K+, Na+, and Cl-; and 4) electrophysiological response due to norepinephrine (NE) stimulus. Current and voltage data attained from literature review was fitted to known equations for these channels. Coupled differential equations were then used along with these parameters to show the dynamic change of ion concentrations, membrane voltage, and gating variables. Validation was done using available literature …