Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biomedical Engineering and Bioengineering (11)
- Molecular, Cellular, and Tissue Engineering (7)
- Chemical Engineering (6)
- Medicine and Health Sciences (5)
- Biomaterials (3)
-
- Medical Sciences (3)
- Biochemical and Biomolecular Engineering (2)
- Cell Biology (2)
- Cell and Developmental Biology (2)
- Chemistry (2)
- Life Sciences (2)
- Medical Biotechnology (2)
- Nanoscience and Nanotechnology (2)
- Physical Sciences and Mathematics (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Animal Structures (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Engineering (1)
- Biology (1)
- Biology and Biomimetic Materials (1)
- Biomedical (1)
- Biomedical Devices and Instrumentation (1)
- Computer Engineering (1)
- Dental Materials (1)
- Dentistry (1)
- Developmental Biology (1)
- Electrical and Computer Engineering (1)
- Institution
- Publication
-
- Esmaiel Jabbari (3)
- Electronic Theses and Dissertations (2)
- Honors Scholar Theses (2)
- Legacy Theses & Dissertations (2009 - 2024) (2)
- All ETDs from UAB (1)
-
- Dissertations (1)
- Engineering Faculty Research (1)
- FIU Electronic Theses and Dissertations (1)
- Masters Theses (1)
- Nima Rahbar (1)
- Pharmacy Faculty Articles and Research (1)
- The Summer Undergraduate Research Fellowship (SURF) Symposium (1)
- Theses and Dissertations - UTB/UTPA (1)
- Tierney GB Deluzio (1)
- Publication Type
- File Type
Articles 1 - 19 of 19
Full-Text Articles in Engineering
When 1 + 1 > 2: Nanostructured Composites For Hard Tissue Engineering Applications, Vuk Uskoković
When 1 + 1 > 2: Nanostructured Composites For Hard Tissue Engineering Applications, Vuk Uskoković
Pharmacy Faculty Articles and Research
Multicomponent, synergistic and multifunctional nanostructures have taken over the spotlight in the realm of biomedical nanotechnologies. The most prospective materials for bone regeneration today are almost exclusively composites comprising two or more components that compensate for the shortcomings of each one of them alone. This is quite natural in view of the fact that all hard tissues in the human body, except perhaps the tooth enamel, are composite nanostructures. This review article highlights some of the most prospective breakthroughs made in this research direction, with the hard tissues in main focus being those comprising bone, tooth cementum, dentin and enamel. …
Cellular Events Under Flow States Pertinent To Heart Valve Function, Glenda L. Castellanos
Cellular Events Under Flow States Pertinent To Heart Valve Function, Glenda L. Castellanos
FIU Electronic Theses and Dissertations
Heart valve disease (HVD) or a damaged valve can severely compromise the heart's ability to pump efficiently. Balloon valvuloplasty is preferred on neonates with aortic valve stenosis. Even though this procedure decreases the gradient pressure across the aortic valve, restenosis is observed soon after balloon intervention. Tissue engineering heart valves (TEHV), using bone marrow stem cells (BMSCs) and biodegradable scaffolds, have been investigated as an alternative to current non-viable prosthesis. By observing the changes in hemodynamics following balloon aortic valvuloplasty, we could uncover a potential cause for rapid restenosis after balloon intervention. Subsequently, a tissue engineering treatment strategy based on …
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve
The Summer Undergraduate Research Fellowship (SURF) Symposium
The field of regenerative medicine seeks to create replacement tissues and organs, both to repair deficiencies in biological function and to treat structural damage caused by injury. Scaffoldings mimicking extracellular matrix (ECM), the structure to which cells attach to form tissues, have been developed from synthetic polymers and also been prepared by decellularizing adult tissue. However, the structure of ECM undergoes significant remodeling during natural tissue repair, suggesting that ECM-replacement constructs that mirror developing tissues may promote better regeneration than those modeled on adult tissues. This work investigated the effectiveness of a method of viewing the extracellular matrix of developing …
Natural Polymer Based Composite Scaffolds For Tissue Engineering Applications, Marcos R. Villarreal
Natural Polymer Based Composite Scaffolds For Tissue Engineering Applications, Marcos R. Villarreal
Theses and Dissertations - UTB/UTPA
The fabrication, characterization, and bio-assessment of two types of perspective tissue engineering (TE) scaffolds are presented. Principally derived of biopolymers, both types of scaffolds generally followed porous scaffold methodologies for synthesis. Differentiating the two scaffold varieties was chiefly driven by crosslinking attainment, where crosslinking is argued to add structural stability and aid in regulating biodegradability rates in TE scaffolds. Microwave irradiation via conventional microwave was one method used to prospectively crosslink cornstarch to chitosan and sodium alginate. Triethyl orthoformate, was used to prospectively crosslink collagen and chitosan. After the scaffolds were “crosslinked” they were subjected to freeze drying techniques in …
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Masters Theses
Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Electronic Theses and Dissertations
Biomaterials used for tissue engineering, specifically polymers, come from either naturally occurring, like gelatin or collagen, or synthetic sources, such as polyesters. Often times, it is advantageous to combine biomaterials in order to maximize certain material properties, such as cellular adhesion and degradation. The purpose of this study is to provide direction for the synthesis, characterization, and a combination of a combination biomaterial between fish glue (FG), a natural source polymer, and poly-lactic-co-glycolic acid (PLGA), a synthetically made polyester. First, FG is characterized for molecular weight via Gel Permeation Chromatography, GPC. Two combination methods to mix FG/PLGA solutions are then …
Model Of A Tubular Perfusion Bioreactor Using Computational Fluid Dynamics., Matthew James Robeson 1991-
Model Of A Tubular Perfusion Bioreactor Using Computational Fluid Dynamics., Matthew James Robeson 1991-
Electronic Theses and Dissertations
Through recent years, many novel bioreactor designs for tissue engineering have emerged. The Tubular Perfusion System (TPS) is one such bioreactor for bone and cartilage tissue engineering. The TPS is a perfusion type bioreactor, in which media flows through a bed of scaffold beads. The advantage of this system over similar designs is that it requires no special fabrication techniques and operates at low pressure. Experimental trials have shown increased osteoblastic differentiation and mineralization of bone tissue grown using the TPS versus static culture. The effectiveness of the TPS in promoting osteoblastic differentiation is believed to be due to enhanced …
Piezoelectric Scaffolds For Osteochondral Defect Repair, Sita Mahalakshmi Damaraju
Piezoelectric Scaffolds For Osteochondral Defect Repair, Sita Mahalakshmi Damaraju
Dissertations
Osteoarthritis is one of the most prevalent causes of disability affecting nearly 27 million Americans. Osteoarthritis is caused when extensive damage occurs to the articular cartilage later spreading to the underlying subchondral bone, resulting in osteochondral defects. The current clinical therapies aim at regenerating the hyaline cartilage, but instead fibrocartilage forms at the osteochondral defect site, which is inferior in structure and function and fails to integrate with the surrounding tissue. A biomimetic scaffold, which can provide cues similar to the native extracellular matrix, may facilitate osteochondral defect repair. Articular cartilage and bone extracellular matrix have been shown to produce …
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tierney GB Deluzio
The development of a strategy to improve oxygen delivery to cells seeded on scaffolds is essential for the success of tissue engineering applications. The focus of this work was to explore the application of cyclodextrin inclusion complexes (CD:ICs) with perfluorocarbons as oxygen carriers. CD:ICs were prepared from alpha-cyclodextrin and perfluoroperhydrophenanthrene via co-precipitation, paste mixing, and dry mixing complexation techniques. Characterization indicated that paste mixing at a 2:1 host:guest ratio was the most effective method for complexation between the parent molecules. The CD:ICs were then successfully incorporated in 3D fibrous mats via electrospinning with poly(carbonate urethane) and polycaprolactone as biostable and …
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Design And Development Of Two Component Hydrogel Ejector For Three-Dimensional Cell Growth, Thomas Dunkle, Jessica Deschamps, Connie Dam
Honors Scholar Theses
Hydrogels are useful in wound healing, drug delivery, and tissue engineering applications, but the available methods of injecting them quickly and noninvasively are limited. The medical industry does not yet have access to an all-purpose device that can quickly synthesize hydrogels of different shapes and sizes. Many synthesis procedures that have been developed result in the formation of amorphous hydrogels. While generally useful, amorphous hydrogels exhibit limited capability in tissue engineering applications, especially due to their viscous properties. This endeavor aims to modulate the appropriate gelation parameters, optimize the injection process, and create a prototype that allows for the extrusion …
Finite Element Analysis Of The Application Of Ultrasound-Generated Acoustic Radiation Force To Biomaterials, Nicole J. Piscopo
Finite Element Analysis Of The Application Of Ultrasound-Generated Acoustic Radiation Force To Biomaterials, Nicole J. Piscopo
Honors Scholar Theses
While most bone fractures can heal simply by being stabilized, others can take a longer time to rejoin or they could fail to merge back together completely. Numerous studies have shown the positive effects that ultrasonic therapy have had on delayed-union and non-union bone fracture repair but little is known as to what specific biological mechanisms are at play. Ultrasound may be a valuable tool for bone tissue regeneration at these fracture sites using a tissue engineering approach, however, more must be understood about its impact on stimulating tissues to heal before this can be a reality. For that reason, …
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Nanoparticles For Stem-Cell Engineering, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Characterization Of Sequential Collagen-Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks And Initial Assessment Of Their Potential For Vascular Tissue Engineering, Dany J. Munoz Pinto, Andrea C. Jimenez-Vergara, T. P. Gharat, M. S. Hahn
Engineering Faculty Research
Collagen hydrogels have been widely investigated as scaffolds for vascular tissue engineering due in part to the capacity of collagen to promote robust cell adhesion and elongation. However, collagen hydrogels display relatively low stiffness and strength, are thrombogenic, and are highly susceptible to cell-mediated contraction. In the current work, we develop and characterize a sequentially-formed interpenetrating network (IPN) that retains the benefits of collagen, but which displays enhanced mechanical stiffness and strength, improved thromboresistance, high physical stability and resistance to contraction. In this strategy, we first form a collagen hydrogel, infuse this hydrogel with poly(ethylene glycol) diacrylate (PEGDA), and subsequently …
Osteogenic Differentiation Of Mesenchymal Stem Cells On Novel Three-Dimensional Poly(L-Lactic Acid)/Chitosan/Gelatin/Β-Tricalcium Phosphate Hybrid Scaffolds, Yousef Mohammadi, Hamid Mirzadeh, Fathollah Moztarzadeh, Masoud Soleimani, Esmaiel Jabbari
Osteogenic Differentiation Of Mesenchymal Stem Cells On Novel Three-Dimensional Poly(L-Lactic Acid)/Chitosan/Gelatin/Β-Tricalcium Phosphate Hybrid Scaffolds, Yousef Mohammadi, Hamid Mirzadeh, Fathollah Moztarzadeh, Masoud Soleimani, Esmaiel Jabbari
Esmaiel Jabbari
No abstract provided.
Synthesis, Material Properties, And Biocompatibility Of A Novel Self-Cross-Linkable Poly(Caprolactone Fumarate) As An Injectable Tissue Engineering Scaffold, Esmaiel Jabbari, Shanfeng Wang, Lichun Lu, James Gruetzmacher, Syed Ameenuddin, Theresa Hefferan, Bradford Currier, Anthony Windebank, Michael Yaszemski
Synthesis, Material Properties, And Biocompatibility Of A Novel Self-Cross-Linkable Poly(Caprolactone Fumarate) As An Injectable Tissue Engineering Scaffold, Esmaiel Jabbari, Shanfeng Wang, Lichun Lu, James Gruetzmacher, Syed Ameenuddin, Theresa Hefferan, Bradford Currier, Anthony Windebank, Michael Yaszemski
Esmaiel Jabbari
No abstract provided.
3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche
3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche
Legacy Theses & Dissertations (2009 - 2024)
Among ocular pathologies, glaucoma remains the second leading cause of blindness. The molecular mechanisms that lead to glaucoma have been attributed to damage of the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm's canal, regulate and maintain homeostatic responses of aqueous humor outflow. In glaucoma, drainage of aqueous humor into the Schlemm's canal is hindered, leading to an increase in intraocular pressure (IOP). That increase in IOP is directly correlated with retinal ganglion cell death, eliminating the relay of visual information to the thalamus and visual cortex, leading to blindness. Although disturbance in …
Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser
Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser
Legacy Theses & Dissertations (2009 - 2024)
The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. However, brown adipocytes are difficult to transplant in vivo due to the instability of fat, in terms of necrosis and neovascularization, once injected. Thus, 3D cell culture systems that have the potential to mimic adipogenic microenvironments are needed, not only to advance brown fat implantation, but also to better understand the role of brown adipocytes …
Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan
Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan
All ETDs from UAB
Synthetic bone graft biomaterials are considered as a potential alternative to the conventional use of bone grafts, due to their limitless supply and lack of disease transmission. Current synthetic bone graft materials generally lack the necessary combination of biological and mechanical properties for use as a bone graft substitute. Bone is a dynamic tissue that serves biological, chemical and mechanical purpose in the body and it is unlikely that a single component synthetic biomaterial can provide the appropriate combination of mechanical integrity and biological stimulation to replace bone. Multicomponent biomaterials need chemical bonding between the components to prevent phase separation …
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Nima Rahbar
This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …