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Uncoupled Investigation Of Scaffold Modulus And Mesh Size On Smooth Muscle Cell Behavior, Dany Munoz Pinto, Allen Bulick, Mariah Hahn
Uncoupled Investigation Of Scaffold Modulus And Mesh Size On Smooth Muscle Cell Behavior, Dany Munoz Pinto, Allen Bulick, Mariah Hahn
Dany J. Munoz Pinto
Although scaffold material properties are known to critically impact cell behavior, it has proven difficult to correlate specific cell responses to isolated scaffold parameters, inhibiting rational design of scaffold material properties. The aim of this study was to validate a systematic approach for evaluating the influence of initial scaffold modulus and mesh size on cell extracellular matrix (ECM) deposition and phenotype. Poly(ethylene glycol) diacrylate (PEGDA) hydrogels were selected for this study because of their tunable material properties. Following screening of six distinct PEGDA hydrogels, three formulations were identified which permitted uncoupled investigation of scaffold mesh size and modulus within the …