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Full-Text Articles in Engineering
Application Of Inkjet Printing To Tissue Engineering, Thomas Boland, Tao Xu, Brook Damon, Xiaofeng Cui
Application Of Inkjet Printing To Tissue Engineering, Thomas Boland, Tao Xu, Brook Damon, Xiaofeng Cui
Thomas Boland
ecent advances in organ printing technology for applications relating to medical interventions and organ replacement are described. Organ printing refers to the placement of various cell types into a soft scaffold fabricated according to a computer-aided design template using a single device. Computer aided scaffold topology design has recently gained attention as a viable option to achieve function and mass transport requirements within tissue engineering scaffolds. An exciting advance pioneered in our laboratory is that of simultaneous printing of cells and biomaterials, which allows precise placement of cells and proteins within 3-D hydrogel structures. This advance raises the possibility of …
The Use Of Extracellular Matrix As An Inductive Scaffold For The Partial Replacement Of Functional Myocardium., Glenn Gaudette, S Badylak, P Kochupura, I Cohen, S Doronin, A Saltman, T Gilbert, D Kelly, R Ignotz
The Use Of Extracellular Matrix As An Inductive Scaffold For The Partial Replacement Of Functional Myocardium., Glenn Gaudette, S Badylak, P Kochupura, I Cohen, S Doronin, A Saltman, T Gilbert, D Kelly, R Ignotz
Glenn R. Gaudette
Regenerative medicine approaches for the treatment of damaged or missing myocardial tissue include cell-based therapies, scaffold-based therapies, and/or the use of specific growth factors and cytokines. The present study evaluated the ability of extracellular matrix (ECM) derived from porcine urinary bladder to serve as an inductive scaffold for myocardial repair. ECM scaffolds have been shown to support constructive remodeling of other tissue types including the lower urinary tract, the dermis, the esophagus, and dura mater by mechanisms that include the recruitment of bone marrow-derived progenitor cells, angiogenesis, and the generation of bioactive molecules that result from degradation of the ECM. …
Viability And Electrophysiology Of Neural Cell Structures Generated By The Inkjet Printing Method, Tao Xu, Cassie Gregory, Peter Molnar, S Jalota, Sarit Bhaduri, Thomas Boland
Viability And Electrophysiology Of Neural Cell Structures Generated By The Inkjet Printing Method, Tao Xu, Cassie Gregory, Peter Molnar, S Jalota, Sarit Bhaduri, Thomas Boland
Thomas Boland
Complex cellular patterns and structures were created by automated and direct inkjet printing of primary embryonic hippocampal and cortical neurons. Immunostaining analysis and whole-cell patch-clamp recordings showed that embryonic hippocampal and cortical neurons maintained basic cellular properties and functions, including normal, healthy neuronal phenotypes and electrophysiological characteristics, after being printed through thermal inkjet nozzles. In addition, in this study a new method was developed to create 3D cellular structures: sheets of neural cells were layered on each other (layer-by-layer process) by alternate inkjet printing of NT2 cells and fibrin gels. These results and findings, taken together, show that inkjet printing …