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Development And Testing Of A Simulated Closed Loop Drug Delivery System For Chf Patients Under Milrinone Administration, Runa Shah
Theses
The purpose of this thesis project is the development and testing of a simulated closed loop drug delivery (CLDD) system that consists of a pharmacokinetic, physiological, and feedback-controlling model. The focus of this study is on the control of milrinone inflision to maintain cardiac output at desired setpoint range for patients suffering from congestive heart failure (CHF). The simulated CLDD system is written in VisSim dynamic simulation language for an IBM-compatible PC.
Milrinone pharmacokinetics are represented by a three compartment model. The physiological model consists of the cardiovascular system model linked to the pharmacodynamic submodel of milrinone. The feedback-controlling model …