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In Vitro Comparative Biocompatibility Testing Of Carbofilm Coated And Uncoated Polyetherimide For Cardiovascular Application, M. Bosetti, S. Mazzarelli, L. Nicolais, L. Ambrosio, M. Cannas
In Vitro Comparative Biocompatibility Testing Of Carbofilm Coated And Uncoated Polyetherimide For Cardiovascular Application, M. Bosetti, S. Mazzarelli, L. Nicolais, L. Ambrosio, M. Cannas
Cells and Materials
When blood contacts the surface of a material, several processes take place including the activation of coagulation and immune systems. The aim of this work is to study in vitro the biological reactions seen from the point of view of hemocompatibility and cytocompatibility of a new polymer suggested as an artificial surface for cardiovascular applications: Carbofilm® coated polyetherimide (C®PEI) in comparison to polyetherimide (PEI), the uncoated form. PEI and C®PEI showed no signs of acute cytotoxicity although following long term incubation with PEI cytotoxicity was somewhat increased; both materials supported good endothelial cell adhesion with a higher level of cell …