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Full-Text Articles in Engineering
Applications Of Fourier Transform Infrared (Ft-Ir) Microscopy To The Study Of Mineralization In Bone And Cartilage, Adele L. Boskey, Nancy Pleshko, Stephen B. Doty, Richard Mendelsohn
Applications Of Fourier Transform Infrared (Ft-Ir) Microscopy To The Study Of Mineralization In Bone And Cartilage, Adele L. Boskey, Nancy Pleshko, Stephen B. Doty, Richard Mendelsohn
Cells and Materials
Knowledge of the phase, composition, and crystallite size and perfection of the mineral in normal and abnormally calcified tissues provides insight into the mechanism by which this mineral was deposited. These data also can be used to develop rational therapies for pathological conditions characterized by abnormal mineral deposition. As illustrated in this review, coupling of an optical microscope with a Fourier transform infrared (FT-IR) spectrophotometer permits the mapping at 20 μm spatial resolution of changes in mineral characteristics (content, particle size, composition) in the growth plate, in bone biopsies, in mineralizing cell culture systems, and in soft tissue calcifications. Based …
Clinical Applications Of Recombinant Gene Technology: Bone And Cartilage Repair, Thomas A. Einhorn
Clinical Applications Of Recombinant Gene Technology: Bone And Cartilage Repair, Thomas A. Einhorn
Cells and Materials
Over the past decade, the field of molecular biology has given rise to the development of the applied discipline of molecular medicine. Based on recent developments using recombinant gene technology, genetic mapping analysis and other investigational tools, the physician and surgeon is now ready to begin using those instruments in the diagnosis and treatment of musculoskeletal disease. This article reviews the history of scientific exploration in recombinant gene technology as it applies to bone and cartilage repair. Clinical cases are presented to show how the fruits of scientific knowledge may be brought to bear on some of the more challenging …
Fine Structure Of Remodeling Sites On Iliac Cancellous Bone In Senile Osteoporosis: A Study By Scanning Electron Microscopy Using An Improved Organic Specimen Preparation Method, Toshihiko Takita, Tomonori Naguro, Kichizo Yamamoto
Fine Structure Of Remodeling Sites On Iliac Cancellous Bone In Senile Osteoporosis: A Study By Scanning Electron Microscopy Using An Improved Organic Specimen Preparation Method, Toshihiko Takita, Tomonori Naguro, Kichizo Yamamoto
Cells and Materials
We improved on the organic specimen preparation method in order to investigate the details of the functional state of bone in osteoporosis at high magnification level. The usefulness and possibilities of this method are discussed showing fine structural images of remodeling sites. Iliac bones of senile osteoporotic patients obtained by transilial biopsies were studied by scanning electron microscopy (SEM) using the improved preparation method. Excepting the region near the corticoendosteal surface, most of the iliac cancellous bone was composed of thin rod-shaped trabeculae. Remodeling sites on trabeculae appeared as concavities of various sizes and were easily distinguished from inert surfaces. …