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Theses/Dissertations

Chemical engineering

Retrospective Theses and Dissertations

Medicine and Health Sciences

Articles 1 - 8 of 8

Full-Text Articles in Engineering

Directed Growth And Selective Differentiation Of Neural Progenitor Cells Using A Synergistic Combination Of Topographical And Soluble Cues , Jennifer Behr Recknor Jan 2006

Directed Growth And Selective Differentiation Of Neural Progenitor Cells Using A Synergistic Combination Of Topographical And Soluble Cues , Jennifer Behr Recknor

Retrospective Theses and Dissertations

The purpose of this study is to develop strategies to facilitate nerve regeneration using a synergistic combination of guidance cues. We are investigating the cellular mechanisms of development using adult rat hippocampal progenitor cells (AHPCs) and have demonstrated that manipulating a combination of physical, chemical and biological cues can lead to oriented astrocyte and neural progenitor cell outgrowth and can influence progenitor cell differentiation. To provide physical guidance, micropatterned polystyrene (PS) substrates were fabricated and chemically modified with laminin. Astrocytes or AHPCs cultured on these substrates align along the grooves of the patterned surface extending highly elongated processes. To further ...


Engineering Bioerodible Polymers With Tailored Micro/Nanostructure For Vaccine Delivery , Matthew J. Kipper Jan 2004

Engineering Bioerodible Polymers With Tailored Micro/Nanostructure For Vaccine Delivery , Matthew J. Kipper

Retrospective Theses and Dissertations

This work describes the investigation of bioerodible polyanhydrides as controlled drug delivery vehicles. The polymers studied are based on the 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic acid (SA) monomers. These two materials erode at vastly different rates and can be combined in random copolymers or blends to achieve tailored erosion kinetics. The hydrophobic nature of these materials offers the potential to stabilize proteins, and their mutual incompatibility and semicrystallinity provide an interesting phase behavior, which can be exploited to aid in tailoring the release kinetics. Theoretical and experimental description of the microstructure of polyanhydride copolymers reveals the details of ...


Design Of A Bioartificial Nerve Graft , Gregory Edward Rutkowski Jan 1999

Design Of A Bioartificial Nerve Graft , Gregory Edward Rutkowski

Retrospective Theses and Dissertations

Nerve injuries complicate successful rehabilitation more than any other form of trauma because of loss of protective sensibility and tactile discrimination, denervation atrophy of muscles, and pain syndromes. While achieving full function and organ reinnervation after peripheral nerve injury is a challenge, a promising method of improving the rate and success of regeneration is the bioartificial nerve graft (BNG). The BNG developed in the laboratory consists of a porous bioresorbable tube containing cultured Schwann cells that help to direct and support nerve regeneration when used to bridge the gap between the ends of the severed nerve;To aid in the ...


Development Of An Empirical Model Of Human Sweating And A Semi-Empirical Model Of Human Thermoregulation , Jennifer Jane Walker Jan 1999

Development Of An Empirical Model Of Human Sweating And A Semi-Empirical Model Of Human Thermoregulation , Jennifer Jane Walker

Retrospective Theses and Dissertations

The physiology of the human thermoregulatory response to changes in environment and work load has been studied from the perspective of both the physiologist and the engineer. Both fields have brought certain skills and tools to the effort. An effort to bring together the understanding gained from these two perspectives has been lacking. In this work a model for the sweat response and a model for the thermoregulatory response to changes in room temperature were developed. These models were developed using the modeling tools of engineering and the knowledge contained in past experimental data;An empirical model of the sweat ...


The Effects Of Physiological Levels Of Intermittent Pressure On The Development Of Articular Cartilage In Vitro , Scott Edward Carver Jan 1998

The Effects Of Physiological Levels Of Intermittent Pressure On The Development Of Articular Cartilage In Vitro , Scott Edward Carver

Retrospective Theses and Dissertations

A semi-continuous perfusion system has been designed and constructed to deliver physiological levels of hydrostatic pressure to regenerating cell/polymer constructs of articular cartilage over the long term (weeks to months). Prior to being transferred to the pressurized system, equine articular chondrocytes were dynamically seeded onto nonwoven meshes of polyglycolic acid which provide the cells with a three-dimensional growth environment similar to that found in vivo. When applied in an intermittent manner, physiological pressurization at 500 psi was found to stimulate articular chondrocytes to produce regenerated constructs with greater concentrations of sulfated glycosaminoglycan compared to control (unpressurized) constructs, while the ...


Development Of A Coupled Model Of The Cardiorespiratory And Thermoregulatory Systems , Dawn Denise Downey Jan 1998

Development Of A Coupled Model Of The Cardiorespiratory And Thermoregulatory Systems , Dawn Denise Downey

Retrospective Theses and Dissertations

A model of the human body which integrates the variables involved in temperature regulation and blood gas transport within the cardiovascular and respiratory systems is presented in this dissertation. It expands upon previous work developed by the author to model the competition between skin and muscles when both require increased blood flows during exercise and/or heat stress. First, a detailed study of the control relations used to predict skin blood flow was undertaken. Four other control relations employed in the model were also examined and modified as indicated by empirical results found in literature;Several important cases were then ...


A Quantitative Estimation Of Regulation And Transport Limitations In The Human Cardiopulmonary System , Sharmista Chatterjee Jan 1997

A Quantitative Estimation Of Regulation And Transport Limitations In The Human Cardiopulmonary System , Sharmista Chatterjee

Retrospective Theses and Dissertations

The object of this dissertation is to quantitatively describe the regulation of some of the exchange processes within the human body. Conceptually this dissertation is divided into two sections. In the first section a macroscopic view was adopted to describe the overall regulation of the cardiovascular and respiratory systems. These overall system models were used as heuristic tools to gain an understanding of physiological behavior in micro-gravity. In the second section, a microscopic view was used to estimate the role played by the surfactant system of the lung in regulating the transfer of fluid across the pulmonary-capillary wall;The basis ...


Water And Electrolyte Regulation During Space Flight And Exercise , Susan Elizabeth Doty Jan 1994

Water And Electrolyte Regulation During Space Flight And Exercise , Susan Elizabeth Doty

Retrospective Theses and Dissertations

When one is exposed to microgravity, fluid which is normally pooled in the lower extremities is redistributed headward and weight bearing bones begin to demineralize due to reduced mechanical stresses. The kidney, which is the primary regulator of body fluid volume and composition, responds to the fluid shift and bone demineralization by increasing the urinary output of water, sodium, and calcium. This research involves developing a mathematical description of how water and electrolytes are internally redistributed and exchanged with the environment during space flight. Various levels of activity are also considered, since it is believed that exercise can prevent some ...