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Full-Text Articles in Engineering
A New Mathematical Theory For The Dynamics Of Large Tumor Populations, A Potential Mechanism For Cancer Dormancy & Recurrence And Experimental Observation Of Melanoma Progression In Zebrafish, Adeyinka A. Lesi
Dissertations and Theses
Cancer, a family of over a hundred disease varieties, results in 600,000 deaths in the U.S. alone. Yet, improvements in imaging technology to detect disease earlier, pharmaceutical developments to shrink or eliminate tumors, and modeling of biological interactions to guide treatment have prevented millions of deaths. Cancer patients with initially similar disease can experience vastly different outcomes, including sustained recovery, refractory disease or, remarkably, recurrence years after apparently successful treatment. The current understanding of such recurrences is that they depend on the random occurrence of critical mutations. Clearly, these biological changes appear to be sufficient for recurrence, but are they …
Influence Of Fibroblasts On Metastatic Cancer Cell Drug Resistance In A 3d Microfluidic Cell Array, Elizabeth C. Benoy
Influence Of Fibroblasts On Metastatic Cancer Cell Drug Resistance In A 3d Microfluidic Cell Array, Elizabeth C. Benoy
Dissertations and Theses
Modeling an accurate depiction of the tumor microenvironment, (TME), is essential to observe the effect external factors might have on the tumor in vivo. In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the cytotoxic effects these methods might have on the patient. Our lab has previously developed a three layered microfluidic cell array (3D μFCA) to reconstruct the relevantly spatial configuration of tumor and microvasculature found in vivo in order to develop a more efficient tool of high throughput drug discovery and screening. In this study, we optimized this device to …
Discrete Model For Cancer Tumor Growth And Effect Of Chemotherapy, Karim Virani
Discrete Model For Cancer Tumor Growth And Effect Of Chemotherapy, Karim Virani
Dissertations and Theses
Many mathematical models have focused on growth of a single tumor with their spreading rate with some have included its metastasis. Some of the earlier models focus on exponential growth and its shift with time on to a linear model. The Gompertzian model involves a quadratic terms and that limit growth. We looked into Iwata et al paper it discusses a different model and takes into account the growth and metastasis of a tumor population but does not look into tumor shrinking or chemotherapy. Our new model focuses on the extending Iwata et al model to take into account tumor …
A Novel Biomaterial Enables Chemotactic Study Of Motile Central Nervous System-Derived Tumor Cells, Tanya Singh
A Novel Biomaterial Enables Chemotactic Study Of Motile Central Nervous System-Derived Tumor Cells, Tanya Singh
Dissertations and Theses
"The local cell microenvironment plays an important role in maintaining the dynamics of the extracellular matrix (ECM) and the cell-ECM relationship. ECM is a complex network of macromolecules with distinct mechanical and biochemical characteristics [1]. The multifaceted interactions that occur between cells and the ECM are crucial to the regulation of processes that maintain homeostasis. These mechanisms are often deregulated during cancer onset and progression, which cause the ECM to become highly disorganized, alter the cell-matrix interactions, and promote increased hypervascularity and metastasis as these components are indicative of cancer progression. Medulloblastoma (MB) is one of the most common, malignant …