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Full-Text Articles in Engineering
Molecular Basis Of Class Ib Drug Interactions With The Nav Channel Macromolecular Complex: A Route To Personalized Medicine For Cardiac Arrhythmia, Wandi Zhu
McKelvey School of Engineering Theses & Dissertations
The heart rhythm is precisely controlled by the electrical impulse that propagate in the cardiac tissue. In single cardiomyocytes, the electrical activity generated by action potentials (AP). Cardiac NaV channels (NaV1.5) carry a large influx of Na+ that mediates the initiation and propagation of the AP in both atria and ventricles. Disruption of NaV1.5 function by genetic variants or external factors can result in deadly arrhythmias, such as long QT syndrome and Brugada syndrome. Thus, NaV channels are import therapeutic targets. The class I antiarrhythmics are the modulators of the NaV channels. Although they have been used clinically for over …
Transcriptional Regulation Of Arrhythmia: From Mouse To Human, Yun Qiao
Transcriptional Regulation Of Arrhythmia: From Mouse To Human, Yun Qiao
McKelvey School of Engineering Theses & Dissertations
In the last two decades, our understanding of cardiac arrhythmias has been accelerated immensely by the development of genetically engineered animals. Transgenic and knockout mice have been the “gold standard” platforms for delineating disease mechanisms. Much of our understanding of the pathogenesis of atrial and ventricular arrhythmias is gained from mouse models that alter the expression of specific ion channels or other proteins. However, cardiac arrhythmias such as atrial fibrillation are heterogeneous diseases with numerous distinct conditions that could not be explained exclusively by the disruption of ionic currents. Increasing evidence suggests disruption of signaling pathways in the pathogenesis of …
Optical Mapping Of Cardiac Electromechanics, Hanyu Zhang
Optical Mapping Of Cardiac Electromechanics, Hanyu Zhang
All ETDs from UAB
Sudden cardiac arrest is a leading cause of death in the world. One of the common causes of sudden cardiac arrest is acute regional ischemia due to coronary occlusion. However, the mechanism of arrhythmia onset in this setting is still unclear. Previous stud-ies suggest that abnormal mechanical stretch during acute regional ischemia may play a role in initiating arrhythmia through triggering ectopic electrical activation. Optical map-ping has been widely used in cardiac electrophysiological research in the past decades. Compared with conventional electrical mapping techniques, optical mapping offers a number of advantages. But a major limitation of optical mapping is that …
On Designing An Ecg-Based Intelligent System: Utilizing The Heart’S Electrical Activity To Recognize Humans And Detect Arrhythmia, Sara Saeed Abdeldayem
On Designing An Ecg-Based Intelligent System: Utilizing The Heart’S Electrical Activity To Recognize Humans And Detect Arrhythmia, Sara Saeed Abdeldayem
Graduate Theses, Dissertations, and Problem Reports
The electrocardiogram (ECG) signal is the bioelectrical signal that reflects the heart's activity. It has been extensively used as a diagnostic tool since it holds information about the cardiac health condition. However, recent researches have shown that it exhibits an inter-subject variability property. Therefore, it can be used as a biometric-based modality for either identification or verification purposes. Nevertheless, some of the challenges are faced while employing such a signal. For instance, ECG signal is prone to noise, accordingly, noise filters should be designed to remove the noise while keeping the signal properties. Moreover, factors such as medications, health condition, …