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Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Electronic Thesis and Dissertation Repository
The development of a strategy to improve oxygen delivery to cells seeded on scaffolds is essential for the success of tissue engineering applications. The focus of this work was to explore the application of cyclodextrin inclusion complexes (CD:ICs) with perfluorocarbons as oxygen carriers. CD:ICs were prepared from alpha-cyclodextrin and perfluoroperhydrophenanthrene via co-precipitation, paste mixing, and dry mixing complexation techniques. Characterization indicated that paste mixing at a 2:1 host:guest ratio was the most effective method for complexation between the parent molecules. The CD:ICs were then successfully incorporated in 3D fibrous mats via electrospinning with poly(carbonate urethane) and polycaprolactone as biostable and …
Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon
Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon
Electronic Thesis and Dissertation Repository
The development of new and improved biomaterials is essential for tissue engineering and regenerative medicine applications. Amino acid-based polyphosphazenes are being explored as scaffold materials for tissue engineering applications due to their non-toxic degradation products and tunable material properties. This work focuses on the synthesis of non-functional and novel functional poly[(amino acid ester)phosphazene]s using a facile method of thermal ring opening polymerization followed by one-pot room temperature substitution. The family of polyphosphazenes developed in this work is based on L-alanine (PNEAs), L-phenylalanine (PNEFs), and L-methionine (PNEMs) with L-glutamic acid imparting the functionality. Characterization of these materials demonstrated that the one-pot …