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Full-Text Articles in Engineering
Characterization And Assessment Of Mechanical Properties Of Adipose Derived Breast Tissue Scaffolds As A Means For Breast Reconstructive Purposes, Ehsan Omidi
Electronic Thesis and Dissertation Repository
Decellularized adipose tissue (DAT) has shown great potential for use as a regenerative scaffold in breast reconstruction following mastectomies or lumpectomies. Mechanical properties of such scaffolds are of great importance in order to mimic natural adipose tissue. This study focuses on the characterization of mechanical properties and assessment of DAT scaffolds for implantation into a human breast. DAT samples sourced from multiple adipose tissue depots within the body were tested and their elastic and hyperelastic parameters were obtained. Subsequently simulations were conducted where the calculated hyperelastic parameters were tested as a real human breast model under two different gravity loading …
Economic Evaluation Of Potential Applications Of Gene Expression Profiling In Clinical Oncology, Malek Hannouf
Economic Evaluation Of Potential Applications Of Gene Expression Profiling In Clinical Oncology, Malek Hannouf
Electronic Thesis and Dissertation Repository
Histopathological analysis of tumor is currently the main tool used to guide cancer management. Gene expression profiling may provide additional valuable information for both classification and prognostication of individual tumors. A number of gene expression profiling assays have been developed recently to inform therapy decisions in women with early stage breast cancer and help identify the primary tumor site in patients with metastatic cancer of unknown primary. The impact of these assays on health and economic outcomes, if introduced into general practice, has not been determined. I aimed to conduct an economic evaluation of regulatory-approved gene expression profiling assays for …