Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Coupled Fluid-Thermal Analysis Of Low-Pressure Sublimation And Condensation With Application To Freeze-Drying, Arnab Ganguly
Coupled Fluid-Thermal Analysis Of Low-Pressure Sublimation And Condensation With Application To Freeze-Drying, Arnab Ganguly
Open Access Dissertations
Freeze-drying is a low-pressure, low-temperature condensation pumping process widely used in the manufacture of bio-pharmaceuticals for removal of solvents by sublimation. The goal of the process is to provide a stable dosage form by removing the solvent in such a way that the sensitive molecular structure of the active substance is least disturbed. The vacuum environment presents unique challenges for understanding and controlling heat and mass transfer in the process. As a result, the design of equipment and associated processes has been largely empirical, slow and inefficient.^ A comprehensive simulation framework to predict both, process and equipment performance is critical …
Current Steering And Electrode Spanning With Partial Tripolar Stimulation Mode In Cochlear Implants, Ching-Chih Wu
Current Steering And Electrode Spanning With Partial Tripolar Stimulation Mode In Cochlear Implants, Ching-Chih Wu
Open Access Dissertations
Cochlear implants (CIs) partially restore hearing sensation to profoundly deaf people by electrically stimulating the surviving auditory neurons. However, CI users perform poorly in challenging listening tasks such as speech recognition in noise and Cochlear implants (CIs) partially restore hearing sensation to profoundly deaf people by electrically stimulating the surviving auditory neurons. However, CI users perform poorly in challenging listening tasks such as speech recognition in noise and music perception, possibly due to the small number of implanted electrodes and the large current spread of electric stimulation. Although current spread may be reduced using partial tripolar (pTP) stimulation mode, the …