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Full-Text Articles in Engineering
Investigating Teenage Drivers' Driving Behavior Before And After Lag (Less Aggressive Goals) Training Program, Jingyi Zhang
Investigating Teenage Drivers' Driving Behavior Before And After Lag (Less Aggressive Goals) Training Program, Jingyi Zhang
Masters Theses
Motor vehicle crashes are a leading cause of death during adolescence, with the fatal crash rate per mile-driven for 16-19 years old drivers being nearly 3 times larger than the rate for drivers age 20 and older. High gravitational events among teenage drivers, such as quick starts, and hard stops, have been shown to be highly correlated with crash rates. The current younger driver training programs developed in the late 1990s, however, do not appear to be especially effective in regard to many skills which are critical to avoiding crashes. With this in mind, a simulator-based training program aimed at …
Effect Of Chemotherapeutic Treatment Schedule On A Tissue Transport Model, Dan E. Ganz
Effect Of Chemotherapeutic Treatment Schedule On A Tissue Transport Model, Dan E. Ganz
Masters Theses
Current chemotherapeutic treatment schedule prediction methods rely heavily on PK/PD-based models and overlook the important contribution of tissue-level transport and binding. Tissue-level transport and binding phenomena are essential to understanding drug delivery and efficacy in tumors. Drugs with desirable PK/PD properties often fail in vivo due to poor tissue-level transport. We developed an in silico method to predict the effect of treatment schedule on efficacy that couples PK/PD with tissue-level transport. Treatment schedules were implemented on theoretical drugs with different PK/PD and transport properties. For each drug with a given clearance rate, diffusivity, and binding, treatment schedules consisting of one …