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In-Line Microfluidic Particle Preconcentrator And Detector For Continuous Flow Monitoring, Quan Yuan

Doctoral Dissertations

This dissertation presents the design and prototyping of three in-line microfluidic devices for continuous monitoring of particulate flows. The three devices are AC electrokinetic (ACEK) and acoustic sample preconcentration techniques for resettable particle enrichment, and an in-line somatic cell counter for mastitis monitoring.

For the ACEK preconcentrator, ACEK is a new and promising technique to manipulate micro/bio-fluid and particles. There are many advantages over other techniques, such as low applied voltage, low cost, portability and notable biocompatibility of lab-on-a-chip (LOC) device. We successfully developed a 3D multi-level electrode platform to extract bioparticles via AC electroosmosis (ACEO) and negative Dielectrophoresis (DEP). …