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Full-Text Articles in Engineering
Engineering Single-Molecule, Nanoscale, And Microscale Bio-Functional Materials Via Click Chemistry, Michael Daniele
Engineering Single-Molecule, Nanoscale, And Microscale Bio-Functional Materials Via Click Chemistry, Michael Daniele
All Dissertations
To expand the design envelope and supplement the materials library available to biomaterials scientists, the copper(I)-catalyzed azide-alkyne cycloaddition (CuCAAC) was explored as a route to design, synthesize and characterize bio-functional small-molecules, nanoparticles, and microfibers. In each engineered system, the use of click chemistry provided facile, bio-orthogonal control for materials synthesis; moreover, the results provided a methodology and more complete, fundamental understanding of the use of click chemistry as a tool for the synergy of biotechnology, polymer and materials science. Fluorophores with well-defined photophysical characteristics (ranging from UV to NIR fluorescence) were used as building blocks for small-molecule, fluorescent biosensors. Fluorophores …
Thermodynamic Analysis Of Polyethylene Glycol Thiol-Ene Click Chemistry And Surface Modification Of Bacterial Cellulose, Kaan Serpersu
Thermodynamic Analysis Of Polyethylene Glycol Thiol-Ene Click Chemistry And Surface Modification Of Bacterial Cellulose, Kaan Serpersu
Masters Theses
Polyethylene glycol (PEG) has been one of the extensively studied polymers for medical applications. However, the use of PEG can require complicated and low efficiency reactions which can impose limits to potentially useful medical solutions. Click chemistry has recently emerged as a way to avoid these pitfalls by utilizing reactions that are highly efficient and require simple reaction conditions. One such reaction is known as the Michael-addition thiol-ene click reaction (TECC). The combination of PEG with TECC has received some study, but has not been thermodynamically characterized as a click reaction. In this work PEG-TECC reaction kinetics were studied by …