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Hot-Melt Mixing Of Partially Miscible Active Pharmaceutical Ingredient-Polymer Mixtures, Min Yang
Hot-Melt Mixing Of Partially Miscible Active Pharmaceutical Ingredient-Polymer Mixtures, Min Yang
Dissertations
Solid dispersion/solution processes for producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs’ solubility and even bioavailability to a great extent by converting drugs from crystalline to amorphous form. HME can be carried out at two process temperature regimes: one where Tprocess > Tm of the drug and the Tg of the polymer (or the Tm for the case of semi-crystalline polymers); the other at Tm > Tprocess > Tg (Tm for the case of semi-crystalline polymer). Processing below the drug’s …