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Full-Text Articles in Engineering
Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion
Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion
All Dissertations
It is estimated that this year more than 200,000 women in the United States will be diagnosed with breast cancer. Treatment for most occurrences of breast cancer will often include surgical removal of the tumorigenic tissue, resulting in a soft tissue defect within the subcutaneous tissue of the skin. Post-surgical reconstruction methods are often sought by patients to restore the aesthetic function of the breast via cellular or non-cellular methods; however, because of complications associated with currently used methods for breast reconstruction, researchers are investigating tissue engineering methods to produce viable autologous adipose tissue for breast reconstruction.
Previous research in …
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
All Dissertations
Despite over three decades of research in blood-material interactions, the biomaterials field has been unsuccessful in developing a truly non-thrombogenic biomaterial. This is due to an incomplete understanding of the factors underlying biomaterial-associated thrombosis, especially the mechanisms mediating the interactions of platelets with the adsorbed plasma protein layer(s) on the implant surface. The work presented here is motivated by the primary goal of delineating these mechanisms, and understanding the platelet receptors involved, as well as the domains/amino acid sequences they bind to in the protein molecules.
It is critical to differentiate between the amount and the conformation of the adsorbed …
Designing A Whey Protein Based Material As A Scaffold For Bone Regeneration, Mia Dvora
Designing A Whey Protein Based Material As A Scaffold For Bone Regeneration, Mia Dvora
LSU Doctoral Dissertations
A novel gel material was designed and optimized for use as a bone tissue regeneration scaffold. Whey protein isolate (WPI), the primary component of the material, underwent considerable testing for conformity to a set of known material characteristics required for application in bone regeneration. WPI gels of different compositions were fabricated by thermally inducing gelation of high-concentration protein suspensions, and characterized for compressive strength and modulus, hydration swelling and drying properties, mechanical behavior change due to polysaccharide additives, and intrinsic pore network structure. The gels were also tested for their compatibility with MC3T3-E1 cells, and interactions such as cell adhesion, …