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Full-Text Articles in Engineering

Mathematical Modeling Of Transient State Transdermal Drug Delivery, Alison Nickol Weltner May 2004

Mathematical Modeling Of Transient State Transdermal Drug Delivery, Alison Nickol Weltner

Theses

In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.


Engineering Bioerodible Polymers With Tailored Micro/Nanostructure For Vaccine Delivery , Matthew J. Kipper Jan 2004

Engineering Bioerodible Polymers With Tailored Micro/Nanostructure For Vaccine Delivery , Matthew J. Kipper

Retrospective Theses and Dissertations

This work describes the investigation of bioerodible polyanhydrides as controlled drug delivery vehicles. The polymers studied are based on the 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic acid (SA) monomers. These two materials erode at vastly different rates and can be combined in random copolymers or blends to achieve tailored erosion kinetics. The hydrophobic nature of these materials offers the potential to stabilize proteins, and their mutual incompatibility and semicrystallinity provide an interesting phase behavior, which can be exploited to aid in tailoring the release kinetics. Theoretical and experimental description of the microstructure of polyanhydride copolymers reveals the details of ...


Integral Transport Based Deterministic Brachytherapy Dose Calculations , Chuanyu Zhou Jan 2004

Integral Transport Based Deterministic Brachytherapy Dose Calculations , Chuanyu Zhou

Retrospective Theses and Dissertations

Brachytherapy usually refers to a category of procedures where radiation sources are implanted into the tumor or into its close vicinity to deliver high radiation doses into the tumor for a therapy. A feedback about the dose rate distribution during the surgery is desired to guarantee the dose coverage and the success of a treatment. Calculation speed is crucial in this attempt and traditional Monte Carlo methods are not suitable for this purpose.;We developed a deterministic algorithm for computing three dimensional brachytherapy dose distributions. The deterministic algorithm has been based on the integral transport equation. The integral transport equation ...


Dual Energy Scanning Beam X -Radiography, Randolph Frank Wojcik Jan 2004

Dual Energy Scanning Beam X -Radiography, Randolph Frank Wojcik

Dissertations, Theses, and Masters Projects

Dual energy X-radiography is a method first developed in the mid-1970's by which one uses the information contained in the energy spectrum of the transmitted X-ray flux through an object. With this information one can distinguish the types of materials present in a radiograph and thus allow a computer to subtract them from the image enhancing the contrast of the remaining materials. Using this method, one can see details, which would have been hidden by overlying structures of other materials such as seen in radiographs of parts, made up of mixtures of metals and composites. There is also great ...