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Full-Text Articles in Engineering
Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj
Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj
University of Kentucky Master's Theses
Growth plate is a highly organized cartilaginous tissue found at the end of long bones and is responsible for longitudinal growth of the bones. Growth plate fracture leads to retarded growth and unequal limb length, which might have a lifelong effect on a person’s physical stature. This research is a tissue engineering approach for the treatment of growth plate injury. Insulin-like growth factor I (IGF-I), which can stimulate cartilage formation, was encapsulated within PLGA microspheres that were then used to form porous scaffolds. The release profile of the IGF-I from the PLGA scaffold showed a biphasic release pattern. In vitro …
Process For Formation Of Cationic Poly (Lactic-Co-Glycolic Acid) Nanoparticles Using Static Mixers, Yamuna Reddy Charabudla
Process For Formation Of Cationic Poly (Lactic-Co-Glycolic Acid) Nanoparticles Using Static Mixers, Yamuna Reddy Charabudla
University of Kentucky Master's Theses
Nanoparticles have received special attention over past few years as potential drug carriers for proteins/peptides and genes. Biodegradable polymeric poly (lactic-co-glycolic acid) (PLGA) nanoparticles are being employed as non-viral gene delivery systems for DNA. This work demonstrates a scalable technology for synthesis of nanoparticles capable of gene delivery. Cationic PLGA nanoparticles are produced by emulsiondiffusion- evaporation technique employing polyvinyl alcohol (PVA) as stabilizer and chitosan chloride for surface modification. A sonicator is used for the emulsion step and a static mixer is used for dilution in the diffusion step of the synthesis. A static mixer is considered ideal for the …