Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Replacement Options For The Ap1-Lew System, Tiffany M. Sherburn
Replacement Options For The Ap1-Lew System, Tiffany M. Sherburn
Honors Theses
This report details the upgrade of Pfizer’s Active Pharmaceutical Ingredient-Low Endotoxin Water (API-LEW) distribution system. The current system is suffering from chloride induced stress corrosion which has caused pitting and cracking throughout the exterior portions of the loop. The system will eventually fail catastrophically if an update is not undertaken. Many variables and system constraints are considered to maintain the API-LEW grade water.
The system operates at 65 ○C and maintains turbulence to prevent any microbial growth. The distribution loop spans 8,500 feet of 4 inch diameter stainless steel pipe which is carried on trestles that are exterior to …