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Intraoperative Localization Of Subthalamic Nucleus During Deep Brain Stimulation Surgery Using Machine Learning Algorithms, Mahsa Khosravi
Intraoperative Localization Of Subthalamic Nucleus During Deep Brain Stimulation Surgery Using Machine Learning Algorithms, Mahsa Khosravi
Electronic Thesis and Dissertation Repository
This thesis presents a novel technique for localizing the Subthalamic Nucleus (STN) during Deep Brain Stimulation (DBS) surgery. DBS is an accepted treatment for individuals living with Parkinson's Disease (PD). This surgery involves implantation of a permanent electrode inside the STN to deliver electrical current. The STN is a small grey matter structure within the brain, which makes accurate placement a challenging task for the surgical team. Prior to placement of the permanent electrode, intraoperative microelectrode recordings (MERs) of neural activity are used to localize the STN. The placement of the permanent electrode and the success of the stimulation therapy …