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Passive Acoustic Emissions In A V-Blender, Allison Crouter
Passive Acoustic Emissions In A V-Blender, Allison Crouter
Electronic Thesis and Dissertation Repository
The pharmaceutical manufacturing process consists of a number of batch steps; each step must be monitored and controlled to ensure quality standards are met. The development of process analytical technologies (PAT) can improve product monitoring with the aim of increasing efficiency, product quality and consistency and creating a better understanding of the manufacturing process.
This work investigates the feasibility of using passive acoustic emissions (PAE) to monitor particulates in a V-blender. An accelerometer was attached to the lid of a V-blender to measure vibrations from the tumbling solids. A wavelet filter removed the oscillations in the signals from the motion …
Audible Acoustic Emissions For Monitoring High-Shear Granulation, Erin M. Hansuld
Audible Acoustic Emissions For Monitoring High-Shear Granulation, Erin M. Hansuld
Electronic Thesis and Dissertation Repository
High-shear wet granulation is a size enlargement process commonly used by the pharmaceutical industry to improve powder properties for downstream processes, such as tabletting. Granule growth however, is difficult to predict because the final product is sensitive to raw material properties and processing conditions. Development of process analytical technologies (PATs) is recommended by regulators to improve process understanding and monitor quality online.
This work investigates the robustness of AAEs as PAT for high-shear granulation. Condenser microphones suspended in the air exhaust were used to collect AAEs from granulation. Applying power spectral density (PSD) analysis, trends related to wetting and end-point …