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Mathematical Modeling Of Mass Transfer In Microvascular Wall And Interstitial Space, Daekyung Kim
Mathematical Modeling Of Mass Transfer In Microvascular Wall And Interstitial Space, Daekyung Kim
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The dynamics of macromolecular transport across the microvascular wall and into the adjoining interstitial space was studied in the hamster cheek pouch using intravital fluorescence microscopy in combination with digital image processing. Fluorescein isothiocyanate-labe led dextrans (FITC-Dx) of 70,000 and 150,000 daltons were used as tracers. In each experiment, the time-dependent extravasation of FITC-Dx from a leakage site in a blood vessel was videotaped for about 2 hours. The macromolecular transport from individual microvessels was quantified by digital video-image processing. Histograms of the light intensity distributions for selected fields at various times were obtained and then converted to the interstitial …