Engineering Commons^™

The Biological Activity Of Dual-Responsive Glycopolymers For Intracellular Codelivery Of Antigen And Lipophilic Adjuvant, Micaela Shields

Honors Theses

Subunit vaccines present themselves as an attractive alternative to traditional approaches to vaccines, which utilizes whole organisms to trigger an immune response. While these traditional approaches have proven themselves reliable within the history of vaccinations, they generally deliver subpar robust cellular-mediated immunity and pose many safety risks. Composed of proteins and /or peptides, subunit vaccines are safer and more precise alternatives to traditional approaches. However, the pharmacokinetic properties of the macromolecules that make up these vaccines hinder the subunit vaccine’s level of immunogenicity [d1] Examples of this hindrance include but are not limited to aggregation at the injection site and …

Identifying Key Activity Indicators In Rats' Neuronal Data Using Lasso Regularized Logistic Regression, Avery Woods

Honors Theses

This thesis aims to identify timestamps of rats’ neuronal activity that best determine behavior using a machine learning model. Neuronal data is a complex and high-dimensional dataset, and identifying the most informative features is crucial for understanding the underlying neuronal processes. The Lasso regularization technique is employed to select the most relevant features of the data to the model’s prediction. The results of this study provide insights into the key activity indicators that are associated with specific behaviors or cognitive processes in rats, as well as the effect that stress can have on neuronal activity and behavior. Ultimately, it was …

The Use Of Scattering Cancellation To Cloak And Decouple Slot Antennas And Antenna Arrays, Daniel Ferro

Honors Theses

The concept of cloaking has been prevalent in emerging research, being able to hide oneself completely from outside observers would be a huge benefit for covert surveillance and other fields. This idea has expanded past optical invisibility into the field of electromagnetic invisibility. To accomplish this form of cloaking, a non-natural material, called metamaterials, must be used. Furthermore, metamaterials can be used in a variety of different techniques including transformation-based cloaking, transmission line cloaking, and scattering cancellation cloaking. One application of cloaking is to use scattering cancellation to decouple two antennas that are placed too closely together such as in …

Evaluation Of The Geotechnical And Foundation Components On Jud Site, Mirabel W. Nkanor

Honors Theses

This thesis is part of the senior design final project of the Civil Engineering Department at the University of Mississippi. Geotechnical and foundation analyses were done on a proposed construction project for a multi-family home in Orlando, Florida. This evaluation done in this thesis follows the pre-existing geotechnical report on the side, USDA soil reports, ASCE Code 32-01 (Design of Foundations), and ASCE-7 Section 12.31.1 (Foundations and Superstructure-to-Foundation Connections).

A structural system was selected from the proposed location, on the corner of South Conway and Judge Road, and an evaluation of the Bearing Load capacity was completed to determine the …

Optimization Of A Fluidized Bed Reactor For The Production Of Acetone From Isopropyl Alcohol, Andrew Rawls Wasson

Honors Theses

For the optimization of the isopropyl alcohol to acetone process, Unit 1100, the Net Present Value (NPV) was used as the objective function to observe the economic impact of each of the optimization factors being tested. During the optimization process, it is not only important to optimize the process’s profitability but also to ensure that the process operates efficiently and meets product specifications. The goal of this optimization was to alter variables from the base case calculations of Unit 1100 to maximize the NPV of the unit. AVEVA ProII software was used to simulate the process and make changes to …

Pour-Over Coffee Stand With Warmer, Francesca Patawaran

Honors Theses

This project sought to demonstrate the process of bringing a new product into the market, from the initial design and prototyping stage to marketing and, ultimately, mass production. As part of the curriculum of The Haley Barbour Center for Manufacturing Excellence (CME), the project team manufactured fifteen Pour-Over Coffee Stands with electric heating components. We first created a 3D model of the proposed design, ensuring that all components fit together in an assembly. Next, we worked with the lab technicians to create a prototype of the product. Then, we refined the manufacturing process to eliminate waste where possible. Throughout the …

The Antler: The Design And Development Of An Independent Shower Support Stand For Those Living With Lower Extremity Limb Loss, Kylie Wright

Honors Theses

While we do not often think about it, taking a shower is a privilege. Standing in the hot water, cleaning off after a long day outdoors, and taking a moment to simply relax is an experience that most people in the U.S. have participated in. However, about 1.4 million Americans do not have this luxury3. Lower extremity amputees have long been advised to shower while seated for their safety. This population is unable to experience the simple independence that accompanies standing in the shower. Despite the growing rate of amputations each year, no products are currently available on the market …

An Investigation Into The Common Problems Of Lagoon Wastewater Treatment In Kentucky, Kaylee A. Jones

Honors Theses

Lagoon wastewater treatment systems are commonly used in areas that do not have the available resources for typical mechanical wastewater treatment. Lagoon systems consist of multiple preliminary lagoons, but mainly rely on long-term facultative lagoons for most analyte removal. In this study, one particular lagoon wastewater treatment system (named Municipality A Wastewater Treatment Plant) is investigated due to noncompliance with governmental standards provided by the National Pollutant Discharge Elimination System (NPDES). Samples were collected by researchers at 4 different instances inside of the treatment systems. These samples were sent to an analytical laboratory for testing. The readings from these samples …

Development Of Novel Sensor Coating Methodology To Enable Understanding Of Fouling Mechanisms On Ion Exchange Membranes, Andrew Ulmer

Honors Theses

As populations expand and natural water resources are depleted, severe droughts and limited access to clean water have become an increased threat to areas across the world. Effective and economic water treatment methods such as electrodialysis (ED) are vital for combating these threats, especially in developing nations and secluded locations. Organic foulant adsorption on the surface of ion exchange membranes severely limits the capabilities of water desalination systems such as ED along with significantly increasing maintenance costs. Understanding characteristics such as the total amount and rate at which these foulants at specific concentrations adsorb and desorb to the membranes is …

An Analysis Of The Production Of Pharmaceutical-Grade Acetone Via The Dehydrogenation Of Isopropanol (Ipa), Jordan Desplas

Honors Theses

The production of 99.9 wt% acetone from isopropanol in Unit 1100 is designed to start up in 2025 and operate for 12 years after startup. The engineering team was tasked with designing the process, creating an economic model, and optimizing the net present value (NPV). The process was simulated in AVEVA PRO/II Simulation for the design process, and the economic analysis was estimated in Microsoft Excel. Parametric and topological optimization was performed linearly on the unit operations in the process. The NPV was improved by $14M from a base case of $122M to an optimized case of $136M. The project …

Crafting Comfort: The Design And Production Of A High-End Poolside Lounge Chair, John Hollis Tackett, Robert Griffis

Honors Theses

This report focuses on the development, design, and manufacturing of the Adjustable Lounge Chair, a high-end poolside lounge chair created to address un-met customer demand in the market. The investigation began with a market analysis to identify sought-after features not currently offered by competitors' products. This analysis drove the design of the chair, which was developed using CAD software, followed by the construction of a physical prototype to validate the concept.

The chair's innovative features include adjustable lumbar support and chair height, as well as a removable face-piece that enables users to comfortably lie prone without straining their necks. These …

The Engineering Challenges Of Designing And Manufacturing A Tensegrity Cup Stand, Yaniv Goulet, Daniel Ferro

Honors Theses

Progressing from a simple idea into a fully developed product is one of the main goals of any engineer. Through Haley Barbour Center for Manufacturing Excellence’s capstone program, the team was tasked with realizing a tensegrity cup stand. The tensegrity structure consists of a top and a bottom of some form only supporting itself by tension. The team had to research the concept, create an initial design, create a prototype of the product, improve the design after the prototype’s mistakes, apply lean principles to improve the manufacturing efficiency, and analyze all the economic impacts of the engineering decisions. In the …

The Design Estimate Of A Warehouse Refrigeration System, Jackson Dear

Honors Theses

The intention of this project was to provide a design and cost estimate for the refrigeration systems within an industrial cold storage distribution center for Magnolia Country Frozen Foods, Inc. in East Rutherford, NJ. The facility includes eighteen 300,000 ft3 units (200 ft x 100 ft x 15 ft). These units require 200 tons of refrigeration at a maintained temperature of 0oF. This project's scope included choosing an optimal refrigeration system, selecting a refrigerant for use within the system, and providing a cost estimate for the purchase of the refrigeration system equipment and for the yearly cost associated with running …

Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Sydney Ruth Rester, Shelby Lynn Berry

Honors Theses

Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …

Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Shelby Lynn Berry, Sydney Ruth Rester

Honors Theses

Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …

Investigating Myosin Ensemble Force Generation Using Optical Tweezers, Janie Watts

Honors Theses

Myosin is a motor protein that facilitates muscle contraction and movement by stepping along actin filaments using energy from ATP hydrolysis. If myosin or other motors are disrupted throughout the body, it can have many harmful effects. Hypertrophic cardiomyopathy is a disease caused by gene mutations that affect myosin heavy chains in the heart. The tissue of the heart becomes abnormally thick, which can make it more difficult to pump blood or block blood flow out of the heart. Our goal is to discern the mechanistic difference function of a healthy and diseased heart. To accomplish this, we construct model …

Comparative Analysis Of Imputation Methods In Real Estate Data, Connor Donlen

Honors Theses

This project involves comparing different methods of missing data imputation in the context of predicting real estate listing prices. These methods are compared against each other in both their ability to recreate the original data and their effects on a final predictive model. In order to evaluate their effectiveness, first, a predictive model is made using the complete dataset to use as a benchmark for the imputed datasets. Then, a complete dataset is split into 80% training and 20% testing datasets, and missing values are created in the training data using two different missing data mechanisms, missing completely at random …

The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway

Honors Theses

The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …

Analysis Of Hemp Fiber Reinforced Polylactide Composite Under High Strain-Rate, Benjamin Rhoads

Honors Theses

The introduction of hemp fibers into a polylactide (PLA) matrix creates a hemp fiber-reinforced composite with 10% hemp fibers and 90% PLA. Natural fibers are becoming a popular alternative to synthetic fibers since they are environmentally friendly, and hemp-fibers are becoming used more often as the demand for natural fibers increased. A Split-Hopkinson Pressure Bar was used to test this composite against a control group using elastic wave propagation theory. Strain gauges were mounted on the incident and transmission bars of the SHPB to measure the propagation of the wave that caused the strain in the sample, which were used …

Optimization And Analysis Of A Styrene Production Process, Alexis Kimpel

Honors Theses

The production of styrene from ethylbenzene in Unit 500 is designed to start up in 2024 and operate for 12 years after startup. The engineering team was tasked with designing the process, creating an economic model, and optimizing the net present value (NPV). The process was simulated in AVEVA PRO/II Simulation for the design process and to estimate the size of equipment. Parametric and topological optimization was performed subsequently on the unit operations in the process. The NPV was improved by $423M from a base case of -$919M to an optimized case of -$496M. The project is recommended to continue …

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …

Interaction Beyond Nearest Neighbor In Periodic Structures, Sudesh Pathak

Honors Theses

Periodic structures have been of particular interest to researchers and engineers due to their interesting vibrational characteristics leading to applications, namely acoustic filters, and waveguides. Many studies on the interaction of nearest neighbors have been performed. However, such studies are insufficient to understand the variation of band gaps and the maximum number of wave vectors for each frequency. The complex band structure obtained from the interaction beyond nearest neighbors can assist in the development of sophisticated acoustic technologies. This paper primarily emphasizes the study of such interactions with the development of mathematical models based on electrostatic forces, supported by the …

Optimization Of Styrene From Ethylbenzene Case Study, Jabria Daria Thompson

Honors Theses

The following pages detail the optimization process of styrene from ethylbenzene in the Styrene Production Plant, Unit 500. There were two parts of the assignment, each with slightly different end goals. The goal of the first part of the assignment, was to create a process that would effectively and efficiently increase the negative Net Present Value (NPV) of the production plant. Procedures taken in this process included developing a working kinetic process simulation model and optimizing this model through unit operations and heat integration, as well as developing an accurate economic model that will be used to evaluate the proposed …

Increasing Accessibility To Monitoring Ammonia Levels In The Body Through Development Of A Novel Point-Of-Care Breath Ammonia Diagnostic Device, Emily C. Wright, Ashwin M. Sivalingam

Honors Theses

Hyperammonemia is a life-threatening metabolic condition that is characterized by elevated levels of ammonia concentrations in the blood. Resulting from serious conditions such as chronic kidney disease or liver failure, the limited functions of the liver and kidney lead to an increase in blood urea nitrogen (BUN) within the body. Currently, there are a wide variety of treatments for this condition, ranging from various medications to surgical procedures such as liver transplants. However, there is a lack of variety in diagnostic testing methods to determine a patient’s ammonia levels. In most cases, patients will need to schedule a doctor’s appointment …

Effective Green Marketing Strategies On Social Media: Selling Companies And Their Consumers On Investing In Carbon Offsetting And Solar Energy In 2021, Melvin Richard Springer Iv

Honors Theses

In a digital world where consumers and businesses alike care significantly about sustainability and corporate social responsibility (CSR), the success of startup companies hinges on constant, clear, and thoughtful communication. Through my research into successfully marketing such concerns on social media as well as my internship at Clearloop, I discovered some of the best ways to convince both companies and consumers that preserving the planet should be a primary concern for every environmentally conscious company. Companies that ignore their impacts on the environment are synonymous with companies doomed to fail in the 21^st century. Clearloop’s model of partnering with …

Customized Sidearm Case: Leading A Cme Capstone Team From Concept To Production, Robert B. Sharp

Honors Theses

The goal behind this thesis is to document and analyze my performance as the project manager for the Customized Sidearm Case capstone team during the Center for Manufacturing Excellence’s senior capstone experience. The capstone experience begins the fall of students senior year where a select number of product ideas submitted by the students are chosen, and teams are built around these projects. The objective of the project is to walk a product from the concept phase through the entire design process resulting in a full-scale production run during the spring semester. My product pitch of a wooden sidearm case, customized …

Nuclear Energy As A Reliable And Safe Source Of Power Generation, Sarup Dhungana

Honors Theses

There is a high demand of energy for generating civil applicable power in the world and in the USA, correspondingly. The world has been consuming various sources to extract the power to meet its demands. Most of the power sources include renewable and non-renewable sources like fossil fuels, natural gas, coal, water, solar, wind, and nuclear power. Although most of these sources have many advantages in terms of their capacity and cost of production, nuclear power can be categorized as the emerging driving force in the United States and in the world for power generation, because of its reliability and …

Application Of The Formal Design Of Experiments To Deformed Airfoil Testing, Alex Ligman

Honors Theses

Traditionally, one factor at a time (OFAT) testing is used to accomplish wind tunnel
experimentation. OFAT testing is a process whereby one of the defined factors in the experiment is changed while all of the other factors are held constant. Afterwards, a new factor is chosen as the one to be manipulated, and the process is then repeated until all factors have been run through. Due to the possible cost-intensive and time-consuming nature of wind tunnel testing, formal design of experiments (DOE) has begun to be applied to wind tunnel experiments. In doing so, unique analyses can be made that …

Optimization Of An Ethylbenzene To Styrene Production Facility, John Michels

Honors Theses

The purpose of this case study is to optimize the design and production of an ethylbenzene-to-styrene manufacturing facility, Unit 500. Compared to the original base-case design, the optimizations presented in this document will save approximately $337 million dollars without compromising the production requirements or quality. Optimization of this process used net present value as an objective function, with changes centered around the reactors, but also the separation equipment and exchangers prior to separation, as those devices most directly controlled process stream contents and conditions. The second set of reactors was removed in favor of using one optimized set of reactors, …

An Overview Of Barriers To Women In Engineering, Madison Karis

Honors Theses

Engineering remains a heavily male-dominated field despite ongoing efforts to increase diversity. Early experiences within the U.S. education system can strongly influence women’s choices to pursue engineering degrees. Many young students are introduced to engineering through pre-college programs, but these programs may give students an incomplete understanding of careers in engineering. Gender stereotyping and discrimination from teachers, counselors, and professors also strongly affect female students’ majors. Students may be led to believe certain misconceptions about engineering if their teachers have inaccurate perceptions about the field. Women in engineering also face workplace discrimination at a much higher rate than women in …