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Articles 1 - 6 of 6
Full-Text Articles in Engineering
Adaptive Intensity Modulated Radiation Therapy Planning Optimization With Changing Tumor Geometry And Biology Enforcing Both Cumulative And Fraction Size Dose Constraints, Behlul Saka
Graduate Theses and Dissertations
Intensity Modulated Radiation Therapy (IMRT) is a modern technique of delivering radiation treatments to cancer patients. In IMRT technology, intensities must be chosen for the many small unit grids into which the beams are divided to produce a desired distribution of dose at points throughout the body with the goal of maximizing dose delivered to the tumor while sparing healthy tissues from excessive radiation and keeping dose homogeneous across the tumor. Although IMRT plans are optimized as a single overall treatment plan, they are delivered over 30-50 treatment sessions (fractions) and both cumulative and per-fraction dose constraints apply. The extended …
Design And Fabrication Of Nanofluidic Systems For Biomolecule Characterizations, Orain Ansel Hibbert
Design And Fabrication Of Nanofluidic Systems For Biomolecule Characterizations, Orain Ansel Hibbert
Graduate Theses and Dissertations
Nanofluidic channel systems were designed and fabricated by combining MEMS microfabrication with AFM nanolithography. In the fabrication process flow, photolithography was first utilized to pattern microfluidic channels and reservoirs on a 4" Pyrex substrate. Subsequently, atomic force microscopy (AFM) based nanolithography was used to mechanically fabricate nanochannels to connect the microreservoirs which formed the inlet and outlet of the nanofluidic system. A Tap190 Diamond-Like Carbon (DLC) AFM tip with a force constant of 48 N/m and a radius of less than 15 nm was used as the nanolithography tool. The resultant nanochannel ranges from 20 to 80 µm in length …
Synthesis Of Zinc Oxide Nanorods And Use In Biosensor Applications, Anishkumar Manoharan
Synthesis Of Zinc Oxide Nanorods And Use In Biosensor Applications, Anishkumar Manoharan
Graduate Theses and Dissertations
The main aim of this research was to develop a nanorod based biosensor for biomedical applications. In this project I use zinc oxide nanorods as the bio-material for biosensor. I fabricated these nanorods using a solution-based technique. Initially I coated a zinc oxide seed layer as the base. This seed layer was then annealed at 350 degrees for almost 1 hour. As a next step, interdigitated electrodes were fabricated on the top of the seed layer using a lift off process. The zinc oxide nanorods were then grown at 90 degrees for almost 4 hours along the electrodes. In this …
An Empirical Investigation Of Supply Chain Excellence In Healthcare, Brian Keith Smith
An Empirical Investigation Of Supply Chain Excellence In Healthcare, Brian Keith Smith
Graduate Theses and Dissertations
This research is motivated by opportunities to improve the cost and quality of healthcare delivery through improved supply chain processes. This research assesses the quality of the healthcare supply chain and identifies factors that are driving supply chain excellence among organizations in the healthcare industry. The first objective of this research is to assess the state of quality measurement in the healthcare supply chain. The achievement of this first objective is presented in Chapter 3 of this dissertation in the form of a manuscript accepted for publication in The Quality Management Journal. The second research objective is to develop …
Evaluating The Capacity Of A Proton Therapy Facility, Ridvan Gedik
Evaluating The Capacity Of A Proton Therapy Facility, Ridvan Gedik
Graduate Theses and Dissertations
A relatively new consideration in proton therapy planning is the requirement that the mix of patients treated satisfy desired percentages. Since it is very dicult to satisfy an integer number of patients in light of these requirements, deviations from patient mix preferences and their impacts on operational capabilities are of particular interest to healthcare planners. Therefore, we propose a bicriteria mathematical programming model that determines an outpatient schedule maximizing the number of fractions and minimizing the deviations from the patient mix ratios over the planning horizon. The tradeos between the two objectives are identied through analysis of ecient frontiers. Our …
Applying Inventory Control Practices Within The Sisters Of Mercy Health Care Supply Chain, Server Apras
Applying Inventory Control Practices Within The Sisters Of Mercy Health Care Supply Chain, Server Apras
Graduate Theses and Dissertations
This research lays a foundation for the better understanding of the application and acceptance of more advanced inventory control practices within the health care supply chain. The demand characteristics and optimal control policies for pharmaceutical items within a multi-echelon provider network are examined within the framework of a case study. Demand forecasting algorithms were applied to forecast demand for inventory control procedures. A spreadsheet-based inventory planning tool was used to minimize the inventory holding and ordering costs subject to fill rate constraints. The costs of inventory control models are compared to the current ordering and inventory control strategies to document …