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The Production And Characterization Of Chitosan Based Microgels Using A Novel Microfluidic Device To Promote Cell Survival, Kaileen Shevchuk
The Production And Characterization Of Chitosan Based Microgels Using A Novel Microfluidic Device To Promote Cell Survival, Kaileen Shevchuk
Williams Honors College, Honors Research Projects
The purpose of this project is to synthesize and characterize perfluorocarbon modified methacrylamide chitosan (MACF) microgels produced with the use of a capillary-based microfluidic device. Since cell survival and development is highly related to particles physical properties, analysis of microgels set out to determine the particle’s physical properties. I hypothesize that the viscosity of the MACF polymer as well as the amount of photo initiator influence the physical properties of synthesized particles and as a result can generate particles with various features for cell culture in terms of shape, size, charge and swelling abilities. This hypothesis was validated through the …
Degradability Of Poly(Ethylene) Based Microgels And Methods Of Improving High Polydispersity Index, Abrar Alniemi
Degradability Of Poly(Ethylene) Based Microgels And Methods Of Improving High Polydispersity Index, Abrar Alniemi
Williams Honors College, Honors Research Projects
In order to improve upon the utilization of poly(ethylene glycol) (PEG) microgel-based scaffolds in drug delivery applications, this work explores the use of degradable and non-degradable PEG for tunable scaffolds. Previously, issues concerning the required uniformity in microgel size and low polydispersity index have been encountered. As such, methods of refining polymer synthesis, microgel fabrication, and microgel size separation were explored. Overall, no solution has been found to correct the issue for the microgels were still observed to have high polydispersity index regardless of varied troubleshooting alterations.