Engineering Commons^™

Design Of Novel Drug Delivery System And Optimal Dosage Regimens, Kwang Seok Kim

Dissertations

Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was created and posted on a website for free access. The second project dealt with the transdermal heat-assisted delivery of corticosterone. Heat conduction and drug diffusion through the patch and the skin were …

A Comparison Of Software Engines For Simulation Of Closed-Loop Control Systems, Sanket D. Nikam

Theses

A wide array of control system design and simulation software engines is available in market. It includes MATLAB-Simulink, LabVIEW, Maple-MapleSim, Scilab-Scicos, VisSim and Mathematica-Control Professional Suite (CPS). Among all of them MATLAB-Simulink is dominant and widely used software engine. The main aim of this study is to implement different state space control methods for non-linear Furuta pendulum system in each one of them and to compare performance against MATLAB-Simulink.

Different parameters like learning curve, interoperability, flexibility, control design tools, documentation and tech support are considered for efficiency comparison. It is shown that MapleSim has multi-body intuitive physical modeling (acausal) approach …