Engineering Commons^™

Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom

Electronic Theses and Dissertations

Therapeutic proteins are used to successfully treat hemophilia, Crohn's Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated with late stage processing steps of filling, shipping, and delivery. Previous work at the University of Denver demonstrated that fluid cavitation can generate a large number of sub-visible protein particles in ultra clean formulations, but that mitigation can be achieved with fluid property manipulation. The goal of this research was to (1) assess the risk of cavitation under common pharmaceutical manufacturing …

Feature-Based Neuro-Symbolic Networks For Global Diagnostics, Tracy Lynn Schantz

Electronic Theses and Dissertations

Engineered system diagnostics have been researched over the years with many successful results. From transportation systems to office technologies, many have been equipped with self-diagnostic capabilities and are called Smart Machines. In spite of these advances, current diagnostic systems are driven by direct sensory information without much concern for patterns of the system behavior or features associated with them. For large-scale systems with complex dynamics, global as well as local diagnostics become of great importance, where sensory information is used as input for the local diagnostics, and patterns of behavior or features are utilized for global diagnostics.

The main objective …