Engineering Commons^™

Modeling Acute Changes In Bladder Wall Tension, Shape And Compliance During Filling, Firdaweke Habteyes

Theses and Dissertations

The bladder wall consists primarily of detrusor smooth muscle. Tension-sensitive nerves in the bladder wall are responsible for providing bladder fullness information that is interpreted as urgency. Bladder wall tension, and therefore nerve output, is a function of bladder volume, shape and material properties. Studies have shown that the bladder wall exhibits acutely regulated detrusor compliance. In addition, bladder shape throughout filling depends on intra-abdominal forces and material properties of the bladder wall, such as regulated detrusor compliance. This thesis focused on modeling the potential influence of acute changes in bladder compliance, shape and bladder wall tension during filling. Laplace’s …

Capillarity And Two-Phase Fluid Transport In Media With Fibers Of Dissimilar Properties, Thomas M. Bucher Jr.

Theses and Dissertations

Capillarity is a physical phenomenon that acts as a driving force in the displacement of one fluid by another within a porous medium. This mechanism operates on the micro and nanoscale, and is responsible for countless observable events. This can include applications such as absorption in various hygiene products, self-cleaning surfaces such as water beading up and rolling off a specially-coated windshield, anti-icing, and water management in fuel cells, among many others.

The most significant research into capillarity has occurred within the last century or so. Traditional formulations for fluid absorption include the Lucas–Washburn model for porous media, which is …

Analysis And Modeling Of The Roles Of Actin-Myosin Interactions In Bladder Smooth Muscle Biomechanics, Seyed Omid Komariza

Theses and Dissertations

Muscle mechanical behavior potentially plays an important role in some of the most common bladder disorders. These include overactive bladder, which can involve involuntary contractions during bladder filling, and impaired contractility or underactive bladder, which may involve weak or incomplete contractions during voiding. Actin-myosin cross-bridges in detrusor smooth muscle (DSM) are responsible for contracting and emptying the bladder. The total tension produced by muscle is the sum of its preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable preload stiffness (APS), which is characterized by a preload tension curve that can be shifted along the length …

Early Prediction Of Fracture In Bodies Bounded By Random Rough Surfaces, Hector Medina

Theses and Dissertations

Under certain loading conditions, surfaces topography coupled with materials degree of brittleness can significantly compromise the mechanical performance of structures. The foregoing remains valid even if roughness is intentionally introduced for engineering reasons. In either case, stress can concentrate. The case of the stress concentration in surfaces having randomly distributed pits is a problem that, although being very practical, yet it remains unsolved. The complexity of a random configuration renders difficult the problem of analytically finding relationships between surface parameters and markers indicative of mechanical failure. Another difficulty is the reproducibility of replicates of specimens possessing random rough surfaces, for …

Optimal Design Of Geothermal Power Plants, Joshua Clarke

Theses and Dissertations

The optimal design of geothermal power plants across the entire spectrum of meaningful geothermal brine temperatures and climates is investigated, while accounting for vital real-world constraints that are typically ignored in the existing literature. The constrained design space of both double-flash and binary geothermal power plants is visualized, and it is seen that inclusion of real-world constraints is vital to determining the optimal feasible design of a geothermal power plant. The effect of varying condenser temperature on optimum plant performance and optimal design specifications is analyzed. It is shown that condenser temperature has a significant effect on optimal plant design …

Cfd Assessment Of Respiratory Drug Delivery Efficiency In Adults And Improvements Using Controlled Condensational Growth, Ross L. Walenga

Theses and Dissertations

Pharmaceutical aerosols provide a number of advantages for treating respiratory diseases that include targeting high doses directly to the lungs and reducing exposure of other organs to the medication, which improve effectiveness and minimize side effects. However, difficulties associated with aerosolized drug delivery to the lungs include drug losses in delivery devices and in the extrathoracic region of human upper airways. Intersubject variability of extrathoracic and thoracic drug deposition is a key issue as well and should be minimized. Improvements to respiratory drug delivery efficiency have been recently proposed by Dr. P. Worth Longest and Dr. Michael Hindle through the …

A Practical Tool For The Determination Of Surface Stresses In Railroad Bearings With Different Contact Geometries And Load Conditions Using Finite Element Analysis, Michael A. Mason

Theses and Dissertations

The connection between contact geometry and fatigue in tapered roller bearings utilized in the railroad environment is still of interest. Roller bearings for railroad applications are typically precision ground with crowned contact geometries to prevent edge loading of components. This normally results in completely elastic Hertzian contact stresses under standard railcar loads. However, under extreme load conditions, detrimental edge loading has been known to occur. It is proposed to develop a tool, using finite element analysis, that can be utilized to optimize complex raceway crown geometries for severe applications.

A successful implementation of this tool is presented and validated using …

Molecular Dynamics Simulations Of Pure Polytetrafluoroethylene Near Glassy Transition Temperature For Different Molecular Weights, Rawan Al-Nsour

Theses and Dissertations

Fluoropolymers are employed in countless end-user applications across several industries. One such fluoropolymer is polytetrafluoroethylene. This research is concerned with studying and understanding the thermal behavior of polytetrafluoroethylene. Such understanding is critical to predict its behavior in diverse service environments as the polymer ages and for allowing bottom up design of improved polymers for specific applications.

While a plethora of experiments have investigated the thermal properties of polytetrafluoroethylene, examining these properties using molecular dynamics simulations remains in its infancy. In particular, the current body of molecular dynamics research on polytetrafluoroethylene has primarily focused on studying polytetrafluoroethylene phases, its physical nature, …