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Full-Text Articles in Engineering
Benchmarking Small-Dataset Structure-Activity-Relationship Models For Prediction Of Wnt Signaling Inhibition, Mahtab Kokabi
Benchmarking Small-Dataset Structure-Activity-Relationship Models For Prediction Of Wnt Signaling Inhibition, Mahtab Kokabi
Masters Theses
Quantitative structure-activity relationship (QSAR) models based on machine learning algorithms are powerful tools to expedite drug discovery processes and therapeutics development. Given the cost in acquiring large-sized training datasets, it is useful to examine if QSAR analysis can reasonably predict drug activity with only a small-sized dataset (size < 100) and benchmark these small-dataset QSAR models in application-specific studies. To this end, here we present a systematic benchmarking study on small-dataset QSAR models built for prediction of effective Wnt signaling inhibitors, which are essential to therapeutics development in prevalent human diseases (e.g., cancer). Specifically, we examined a total of 72 two-dimensional (2D) QSAR models based on 4 best-performing algorithms, 6 commonly used molecular fingerprints, and 3 typical fingerprint lengths. We trained these models using a training dataset (56 compounds), benchmarked their performance on 4 figures-of-merit (FOMs), and examined their prediction accuracy using an external validation dataset (14 compounds). Our data show that the model performance is maximized when: 1) molecular fingerprints are selected to provide sufficient, unique, and not overly detailed representations of the chemical structures of drug compounds; 2) algorithms are selected to reduce the number of false predictions due to class imbalance in the dataset; and 3) models are selected to reach balanced performance on all 4 FOMs. These results may provide general guidelines in developing high-performance small-dataset QSAR models for drug activity prediction.
Development Of A Highly Sensitive Pressure Sensing System With Custom-Built Software For Continuous Physiological Measurements, Masoud Panahi
Development Of A Highly Sensitive Pressure Sensing System With Custom-Built Software For Continuous Physiological Measurements, Masoud Panahi
Masters Theses
In this work, a pressure sensing system was designed and fabricated by developing a highly sensitive cone-structured pressure sensor with a custom-built software for physiological monitoring applications. A novel highly sensitive cone structured porous polydimethylsiloxane (PDMS) based pressure sensor capable of detecting very low-pressure ranges was developed for respiration monitoring. The pressure sensor was fabricated using a master mold, a hybrid-structured dielectric layer, and fabric-based electrodes. The master mold with inverted cone structures was created using a rapid and precise three-dimensional (3D) printing technique. The dielectric layer, with pores and cone structures, was prepared by annealing a mixture of PDMS, …
Power System Stability Assessment With Supervised Machine Learning, Mirka Mandich
Power System Stability Assessment With Supervised Machine Learning, Mirka Mandich
Masters Theses
Power system stability assessment has become an important area of research due to the increased penetration of photovoltaics (PV) in modern power systems. This work explores how supervised machine learning can be used to assess power system stability for the Western Electricity Coordinating Council (WECC) service region as part of the Data-driven Security Assessment for the Multi-Timescale Integrated Dynamics and Scheduling for Solar (MIDAS) project. Data-driven methods offer to improve power flow scheduling through machine learning prediction, enabling better energy resource management and reducing demand on real-time time-domain simulations. Frequency, transient, and small signal stability datasets were created using the …
Autoplug: An Automated Metadata Service For Smart Outlets, Lurdh Pradeep Reddy Ambati
Autoplug: An Automated Metadata Service For Smart Outlets, Lurdh Pradeep Reddy Ambati
Masters Theses
Low-cost network-connected smart outlets are now available for monitoring, controlling, and scheduling the energy usage of electrical devices. As a result, such smart outlets are being integrated into automated home management systems, which remotely control them by analyzing and interpreting their data. However, to effectively interpret data and control devices, the system must know the type of device that is plugged into each smart outlet. Existing systems require users to manually input and maintain the outlet metadata that associates a device type with a smart outlet. Such manual operation is time-consuming and error-prone: users must initially inventory all outlet-to-device mappings, …
Primary User Emulation Attacks In Cognitive Radio - An Experimental Demonstration And Analysis, Benjamin James Ealey
Primary User Emulation Attacks In Cognitive Radio - An Experimental Demonstration And Analysis, Benjamin James Ealey
Masters Theses
Cognitive radio networks rely on the ability to avoid primary users, owners of the frequency, and prevent collisions for effective communication to take place. Additional malicious secondary users, jammers, may use a primary user emulation attacks to take advantage of the secondary user's ability to avoid primary users and cause excessive and unexpected disruptions to communications. Two jamming/anti-jamming methods are investigated on Ettus Labs USRP 2 radios. First, pseudo-random channel hopping schemes are implemented for jammers to seek-and-disrupt secondary users while secondary users apply similar schemes to avoid all primary user signatures. In the second method the jammer uses adversarial …