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Computer Simulation Of Cerebrovascular Circulation : Assessment Of Intracranial Hemodynamics During Induction Of Anesthesia, Steven D. Wolk
Computer Simulation Of Cerebrovascular Circulation : Assessment Of Intracranial Hemodynamics During Induction Of Anesthesia, Steven D. Wolk
Theses
The purpose of this project was to develop a computer model of cerebrovascular hemodynamics interacting with a pharmacokinetic drug model to examine the effects of various stimuli during anesthesia on cerebral blood flow and intracranial pressure.
The mathematical model of intracranial hemodynamics is a seven compartment constant volume system. A series of resistances relate blood and cerebrospinal fluid fluxes to pressure gradients between compartments. Arterial, venous, and tissue compliance are also included. Autoregulation is modeled by transmural pressure dependent arterial-arteriolar resistance. The effect of a drug (thiopental) on cerebrovascular circulation was simulated by a variable arteriolar-capillary resistance. Thiopental concentration, in …
Computer Simulation Of Intracranial Hemodynamics During The Induction Phase Of Anesthesia, Gopinath P. Sundaram
Computer Simulation Of Intracranial Hemodynamics During The Induction Phase Of Anesthesia, Gopinath P. Sundaram
Theses
The induction of general anesthesia is associated with severe hemodynamic compromises which, in turn, may cause acute elevation of intracranial pressure (ICP). Quantitative assessment of cerebrovascular responses arising from multiple mechanical and pharmacological interventions occurring in a short time interval require a large number of human studies which are difficult to perform. The purpose of this project is to evaluate the effect of various stimuli on the intracranial hemodynamics during induction using a mathematical model of cerebrovascular circulation.
A five compartmental model of the cerebrovascular system is used for our simulation. Autoregulation is modeled by adjusting arterial-arteriolar resistance in order …